Issue 3, 2017

Epigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications

Abstract

Recently, gold nanomaterials and iron oxide nanoparticles (NPs) have attracted much attention due to their unique physical, chemical and biological properties. In this study, polyethyleneimine (PEI)-modified Fe3O4 NPs (inner cores) were first prepared, and then gold shells (AuNSs) were innovatively formed on the cores using epigallocatechin gallate (EGCG) as the reducing agent to obtain Fe3O4-PEI@AuNSs-EGCG core–shell NPs. After PEG modification, the Fe3O4-PEI@AuNSs-EGCG/PEG nanoplatform was completed. This highly integrated nanoplatform has shown remarkable biostability, rapid cellular uptake, and excellent in vitro and in vivo anti-tumour activity. Moreover, this nanoplatform can also be used as a magnetic resonance (MR)/X-ray dual-mode imaging agent. In all, the results of this study showed that Fe3O4-PEI@AuNSs-EGCG/PEG is a promising, potentially effective, theranostic nanoplatform for tumour treatment.

Graphical abstract: Epigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications

Supplementary files

Article information

Article type
Paper
Submitted
16 Sep 2016
Accepted
02 Dec 2016
First published
06 Dec 2016

J. Mater. Chem. B, 2017,5, 454-463

Epigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications

Y. Yin, L. Cui, F. Yan, Z. Zhang, W. Li and L. Wang, J. Mater. Chem. B, 2017, 5, 454 DOI: 10.1039/C6TB02408D

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