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Correction: A simple and traceless solid phase method simplifies the assembly of large peptides and the access to challenging proteins

N. Ollivier , R. Desmet , H. Drobecq , A. Blanpain , E. Boll , B. Leclercq , A. Mougel , J. Vicogne and O. Melnyk *
UMR CNRS 8161 CNRS, Université de Lille, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59021 Lille Cedex, France. E-mail: oleg.melnyk@ibl.cnrs.fr

Received 21st June 2017 , Accepted 21st June 2017

First published on 7th July 2017


Correction for ‘A simple and traceless solid phase method simplifies the assembly of large peptides and the access to challenging proteins’ by N. Ollivier et al., Chem. Sci., 2017, DOI: 10.1039/c7sc01912b.


The authors regret that entries 2 and 3 in Table 1 are incorrect in the original manuscript. Entry 2 is missing the CH2CH2O group and entry 3 is missing two carbonyl groups.

A corrected version of Table 1 has been presented below:

Table 1 Linker strategies for solid phase protein synthesis in the N-to-C direction
Entry Functional linker (FL) Attachment method for peptide segment 1 Latent thioester (LT) Cleavage Ref.
Structure Activation method
a The method was used for the synthesis of large protein mimetics through CuAAC ligation.
1 image file: c7sc90046e-u1.tif Oximation pH 4 image file: c7sc90046e-u2.tif Alkylation with bromoacetic acid, pH 4.6 β-Elimination, aqueous base, pH 13 22
2 image file: c7sc90046e-u3.tif CuAAC pH 7 or SPAAC pH 2 image file: c7sc90046e-u4.tif Reduction (TCEP) and exchange by 3-mercaptopropionic acid, pH 4 See entry 1 40
3 image file: c7sc90046e-u5.tif CuAAC Notea Transimination, 1 M H2NOH, pH 7–8.5 44
4 (This work) image file: c7sc90046e-u6.tif Oximation pH 3–4 image file: c7sc90046e-u7.tif See entry 2 Transoximation 0.025 M H2NOH, 3 M aniline, pH 3


The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


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