Issue 24, 2017

An efficient synthesis of novel spiroindenopyridazine-4H-pyran derivatives

Abstract

A convenient one-pot protocol was developed for the synthesis of spiro[indeno[2,1-c]pyridazine-9,4′-pyran]-3′,4-dicarbonitrile derivatives by the reaction of cyanoacetohydrazide, ninhydrin, malononitrile and various cyclic CH-acids under reflux condition in ethanol. No hazardous solvent or catalyst was used in this method. The main advantages of this procedure are the availability of starting materials, very high yields and easy purification.

Graphical abstract: An efficient synthesis of novel spiroindenopyridazine-4H-pyran derivatives

Supplementary files

Article information

Article type
Paper
Submitted
07 Sep 2017
Accepted
01 Nov 2017
First published
10 Nov 2017

New J. Chem., 2017,41, 14954-14959

An efficient synthesis of novel spiroindenopyridazine-4H-pyran derivatives

M. Bayat and H. Hosseini, New J. Chem., 2017, 41, 14954 DOI: 10.1039/C7NJ03397D

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