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Correction: The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

Tim Cernak *a, Kevin D. Dykstra b, Sriram Tyagarajan b, Petr Vachal b and Shane W. Krska b
aMerck Research Laboratories, Discovery Chemistry - Automation & Capabilities Enhancement, 33 Avenue Louis Pasteur, BMB2-116B, Boston, Massachusetts 02115, USA. E-mail: timothy_cernak@merck.com; Tel: +1 617 992 2366
bMerck Research Laboratories, Discovery Chemistry - Automation & Capabilities Enhancement, Rahway, New Jersey, USA

Received 2nd March 2017

First published on 10th March 2017


Correction for ‘The medicinal chemist's toolbox for late stage functionalization of drug-like molecules’ by Tim Cernak et al., Chem. Soc. Rev., 2016, 45, 546–576.


Clopidogrel (compound 105 in Fig. 10) was mistakenly drawn with a meta-chloro substituent whereas the actual drug has an ortho-chloro substituent, as shown in the corrected figure below. Since compound 105 was used as a hypothetical substrate with which to demonstrate the strategy of late-stage functionalization, the proposed reactivity of C–H bonds will be affected by this change. The correct structure with the updated hypothetical late-stage functionalization strategy is shown in the corrected figure below. The authors apologize for any inconvenience this may have caused.
image file: c7cs90023f-u1.tif

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


This journal is © The Royal Society of Chemistry 2017