Issue 15, 2017

Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

Abstract

A series of [Re(I)L(CO)3]+ complexes (where L is a bifunctional bis(NHC)–amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.

Graphical abstract: Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

Supplementary files

Article information

Article type
Communication
Submitted
19 Dec 2016
Accepted
17 Jan 2017
First published
17 Jan 2017

Chem. Commun., 2017,53, 2311-2314

Rhenium(I) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

C. Y. Chan, A. Noor, C. A. McLean, P. S. Donnelly and P. J. Barnard, Chem. Commun., 2017, 53, 2311 DOI: 10.1039/C6CC10066J

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