Open Access Article
This Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence

Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand

Lei Yang, Romain Melot, Markus Neuburger and Olivier Baudoin*
University of Basel, Department of Chemistry, St. Johanns-Ring 19, CH-4056 Basel, Switzerland. E-mail:

Received 7th September 2016 , Accepted 8th October 2016

First published on the web 11th October 2016

The first efficient palladium(0)-catalyzed enantioselective C(sp3)–H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.


Transition-metal catalysis has developed as a powerful tool to activate otherwise unreactive C(sp3)–H bonds and create a variety of carbon–carbon and carbon–heteroatom bonds.1,2 In this context, our group3 as well as others4 have reported the construction of a diverse array of fused carbocycles and heterocycles via intramolecular palladium(0)-catalyzed arylation of unactivated C(sp3)–H bonds from aryl halides. In the last five years, enantioselective versions of these reactions have been disclosed. In particular, the groups of Kündig,5 Kagan,6 and Cramer7a reported the highly enantioselective construction of (fused) indolines using chiral N-heterocyclic carbene or phosphine ligands (Table 1, entry 1). In parallel, we have reported the diastereo- and enantioselective synthesis of (fused) indanes containing up to three adjacent stereocenters by using chiral Binepine ligands.8 Computational mechanistic studies indicated that the C–H bond cleavage occurs through proton abstraction by the coordinated base, usually either a carbonate or an in situ generated carboxylate (concerted metalation-deprotonation mechanism).3b,c,4f,h,5c,d,9,10 In this scenario, not only the ancillary ligand, but also the base should be able to interact with the substrate via non-covalent bonding, and hence induce stereoselective C–H bond cleavage. The possibility that enantioselectivity can be achieved solely using a chiral base was already explored in the above-mentioned work by Kagan6 and Cramer.7a Indeed, the former observed an e.r. of 65[thin space (1/6-em)]:[thin space (1/6-em)]35 in the presence of 50 mol% of Boc-valine in the absence of an ancillary ligand (entry 2), whereas the latter reported an e.r. of 71[thin space (1/6-em)]:[thin space (1/6-em)]29 using a chiral tetralinecarboxylic acid and an achiral NHC ligand (entry 3).11,12 In both cases the indoline product was, however, obtained in low yield.
Table 1 Chiral ligand- vs. chiral base-catalyzed asymmetric C(sp3)–H arylationa

image file: c6sc04006c-u1.tif

Entry L Brønsted acid RYO2H e.r. (yield) ref.
a IPr = 1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene; BPA = binol-derived phosphoric acid.
1 Chiral NHC or phosphine Achiral RCO2H Up to 99[thin space (1/6-em)]:[thin space (1/6-em)]1 Kündig5
Up to 97[thin space (1/6-em)]:[thin space (1/6-em)]3 Kagan6
Up to 98[thin space (1/6-em)]:[thin space (1/6-em)]2 Cramer7a
2 None image file: c6sc04006c-u2.tif 65[thin space (1/6-em)]:[thin space (1/6-em)]35 (Traces) Kagan6
3 IPr image file: c6sc04006c-u3.tif 71[thin space (1/6-em)]:[thin space (1/6-em)]29 (20%) Cramer7a
4 PCy3 3,3′-CF3Ph-BPA Up to 98[thin space (1/6-em)]:[thin space (1/6-em)]2 This work

Encouraged by these precedents, we looked for a suitable chiral Brønsted acid pre-catalyst, which upon in situ deprotonation with a stoichiometric inorganic base, would allow the achievement of both efficiency and high enantioselectivity. Our attention turned toward binol-derived phosphoric acids (BPAs), which are readily available, and have proven to be competent stereochemical inducers in other types of reactions involving cooperative catalysis with Pd complexes,13,14 and, as shown recently by Duan and co-workers, in PdII-catalyzed directed asymmetric C(sp3)–H arylation.15 When the current work was in progress, the same group reported two examples of Pd0-catalyzed enantioselective synthesis of indolines using the simplest BPA, devoid of substituents at the 3,3′-positions, with a moderate e.r. and yield.16

Herein, we show that high levels of enantioselectivity and efficiency can be obtained through the careful choice of BPA substituents and optimization of reaction conditions (entry 4).

Results and discussion

We set out to explore the asymmetric C–H arylation of prototypical substrate 1a bearing enantiotopic methyl groups (Table 2). The well-defined Pd(PCy3)2 complex (5 mol%) was initially chosen as catalyst to minimize the effect of additional ancillary ligands or anions. In order to have a blueprint for the design of an efficient BPA catalyst, we considered the putative κ2-coordinated intermediate13g derived from 3,3′-disubstituted BPAs, which would undergo C–H activation via a phosphate-induced CMD mechanism (Fig. 1, left). In this crude model, a 3′-aryl substituent would sit below the N-isopropyl and CO2Me groups of the substrate, thereby enabling non-covalent interactions. Fig. 1 (right) shows the DFT-optimized structure of the κ2 complex with the optimal (vide infra) BPA 3g, which provides a more accurate picture. According to this model, the modulation of the steric and/or electronic properties of the 3,3′-aryl substituents could allow the introduction of enantioselectivity by discriminating the two enantiotopic methyl groups of the N-isopropyl residue.
Table 2 Optimization of reaction conditions

image file: c6sc04006c-u4.tif

Entry BPA Catalysta n Solvent Temp. (°C) e.r. of 2ab Yield of 2ac (%)
a 5 mol% Pd(PCy3)2 (entries 1–15) or 2.5 mol% Pd2dba3/10 mol% PR3 (entries 16–20).b Enantiomeric ratio measured via HPLC using a chiral stationary phase.c Yield of isolated product.d Reaction time: 40 h.e With 4 Å powdered molecular sieves.f Estimated based on GCMS ratio. DME = 1,2-dimethoxyethane.
1 3a Pd(PCy3)2 1.5 Xylenes 140 52[thin space (1/6-em)]:[thin space (1/6-em)]48 80
2 3b Pd(PCy3)2 1.5 Xylenes 140 50[thin space (1/6-em)]:[thin space (1/6-em)]50 65
3 3c Pd(PCy3)2 1.5 Xylenes 140 54[thin space (1/6-em)]:[thin space (1/6-em)]46 68
4 3d Pd(PCy3)2 1.5 Xylenes 140 52[thin space (1/6-em)]:[thin space (1/6-em)]48 71
5 3e Pd(PCy3)2 1.5 Xylenes 140 57[thin space (1/6-em)]:[thin space (1/6-em)]43 39
6 3f Pd(PCy3)2 1.5 Xylenes 140 56[thin space (1/6-em)]:[thin space (1/6-em)]44 45
7 3g Pd(PCy3)2 1.5 Xylenes 140 80[thin space (1/6-em)]:[thin space (1/6-em)]20 50
8 3h Pd(PCy3)2 1.5 Xylenes 140 57[thin space (1/6-em)]:[thin space (1/6-em)]43 50
9 3g-[H8] Pd(PCy3)2 1.5 Xylenes 140 50[thin space (1/6-em)]:[thin space (1/6-em)]50 63
10d 3g Pd(PCy3)2 1.5 Xylenes 120 87[thin space (1/6-em)]:[thin space (1/6-em)]13 24
11 3g Pd(PCy3)2 3 Xylenes 120 84[thin space (1/6-em)]:[thin space (1/6-em)]16 56
12 3i Pd(PCy3)2 3 Xylenes 120 84[thin space (1/6-em)]:[thin space (1/6-em)]16 50
13 3j Pd(PCy3)2 3 Xylenes 120 55[thin space (1/6-em)]:[thin space (1/6-em)]45 15
14 3g Pd(PCy3)2 3 DMEe 120 96[thin space (1/6-em)]:[thin space (1/6-em)]4 86
15 Pd(PCy3)2 3 DMEe 120 29
16 3g Pd2(dba)3 3 DMEe 120 <2f
17 3g Pd2(dba)3/PCy3 3 DMEe 120 95[thin space (1/6-em)]:[thin space (1/6-em)]5 61
18 3g Pd2(dba)3/PPh3 3 DMEe 120 91[thin space (1/6-em)]:[thin space (1/6-em)]9 <20f
19 3g Pd2(dba)3/PCyp3 3 DMEe 120 97[thin space (1/6-em)]:[thin space (1/6-em)]3 24
20 3g Pd2(dba)3/P(t-Bu)2Me 3 DMEe 120 97[thin space (1/6-em)]:[thin space (1/6-em)]3 <20f

image file: c6sc04006c-f1.tif
Fig. 1 Structural basis for the design of BPA catalysts. aPBE0-D3/Def2SVP, SMD; most H atoms are omitted for clarity.

Following this hypothesis, an array of 3,3′-disubstituted BPAs were synthesized from (R)-binol according to literature procedures17 and were tested as catalysts (10 mol%) in combination with stoichiometric cesium carbonate in xylenes. The most representative results are shown in Table 2.18 The nature of the 3,3′-substituents was indeed found to be crucial, with methyl (entry 1), phenyl (entry 2) or extended aryl groups (entries 3–4) leading to very low levels of enantioselectivity.

meta-Substituents on the 3,3′-phenyl rings led to the first interesting results (entries 5–8). The highest e.r. (80[thin space (1/6-em)]:[thin space (1/6-em)]20) was obtained with commercially available BPA 3g bearing meta-CF3 substituents (entry 7),19 which performed much better than the sterically comparable isopropyl (entry 6) or likewise electron-withdrawing nitro (entry 8) groups. As shown with the partially hydrogenated analogue 3g-[H8] (entry 9), the dihedral angle of the binaphthyl system seems to be a critical factor as well. Decreasing the temperature to 120 °C enabled a significant increase in the e.r., albeit at the expense of the yield (entry 10, compared with entry 7). We hypothesized that the low solubility of cesium carbonate in xylenes and the resulting incomplete deprotonation of the BPA was responsible for the observed low reactivity at 120 °C. Gratifyingly, increasing the amount of Cs2CO3 to 3 equiv. allowed an increase in the yield to 56% (entry 11). Modulating the acidity of the BPA20 by synthesizing phosphoramides 3i–j was met with little success (entries 12–13). In contrast, a major improvement was found when using DME as the solvent. Moreover, the addition of 4 Å molecular sieves proved beneficial, leading to compound 2a in excellent yield and e.r. (entry 14). It is worth noting that a slow but significant background racemic reaction occurred with cesium carbonate alone, in the absence of BPA (entry 15). Among all of the stoichiometric bases tested in combination with catalytic acid 3g, cesium carbonate proved to be optimal. Finally, the effect of the ancillary ligand was investigated in combination with Pd2dba3 (entries 16–20). No reaction occurred without phosphine ligand (entry 16), and PCy3 furnished the highest reactivity (entry 17) among the tested monophosphines. It is noteworthy that the in situ combination of Pd2dba3 and PCy3 provided the same e.r. as the well-defined Pd(PCy3)2 complex, but the latter was found to be a more active catalyst (compare entries 14 and 17). Hence, under optimal conditions, indoline 2a was obtained in 86% yield and 96[thin space (1/6-em)]:[thin space (1/6-em)]4 e.r. (entry 14). The (S) absolute configuration of the major enantiomer was ascribed via X-ray diffraction analysis of a derivative (vide infra). These levels of reactivity and selectivity are comparable to those obtained on the same substrate with the chiral ancillary ligand approach.21

The scope and limitations were next studied under these optimized conditions (Scheme 1), starting with reactants bearing a trisubstituted carbon adjacent to the nitrogen atom (R2 = H, Scheme 1a). Among the different tested halides (X = Cl, Br, I), the bromide was found to be optimal. Importantly, the reaction could be performed from 1.36 g (5 mmol) of the latter with equal efficiency and stereoselectivity. From the corresponding iodide, the e.r. was similar (96[thin space (1/6-em)]:[thin space (1/6-em)]4) but the yield was significantly lower (68%). The chloride was less reactive under the same conditions, and lower yield and e.r were obtained even at 140 °C. The effect of the nitrogen substituent (R1) was next investigated (indolines 2b–g). Carbamates were found to be optimal (2a–d), whereas other groups gave rise to lower yields (2f–g) and enantioselectivities (2e, 2g). This important effect of the nitrogen substituent is consistent with the model described in Fig. 1, which shows the proximity of the CO2Me group with the 3′-aryl substituent of the BPA.

image file: c6sc04006c-s1.tif
Scheme 1 Scope and limitations of the enantioselective C(sp3)–H arylation reaction. The shown absolute configurations of the major enantiomers were deduced from those of 2a and 2u (see Scheme 3). a Performed at 140 °C. b Performed at 100 °C.

In addition, the reaction was found to tolerate electronically diverse substituents at various positions (R3–R5) on the aromatic ring (2h–s), including ester (2k), cyano (2l) and amino (2o) groups. High yields and e. r. were obtained for all of the substrates except for those bearing Me or Cl substituents at the C-5 (R3) and C-7 (R5) positions of the indoline ring, which seem to be more sensitive. In addition to indolines, azaindoline 2t was obtained with satisfying yield and stereoselectivity.

So far, both the chiral ligand5–7 and the chiral base approaches allow access to scalemic indolines containing a trisubstituted stereocenter. In addition to these compounds, interesting new types of indolines were targeted (Scheme 1b and c). First, indoline 2u containing a tetrasubstituted stereocenter was obtained with good yield and e.r., despite the more crowded environment of the enantiotopic methyl groups. Interestingly, the carbonyl substituents on the adjacent carbon (2v) and nitrogen (2w) atoms were found to have a significant impact on both the yield and enantioselectivity, with smaller methoxycarbonyl groups being optimal (2u). Gratifyingly, substituted analogues of 2u (2x–z) were obtained with comparable enantioselectivity. The current method represents a simple enantioselective route to these valuable tetrasubstituted amino acid precursors, which does not involve chemical or enzymatic resolution.22

Various indolines fused to five-, six- and seven-membered rings have been synthesized via enantioselective C–H arylation in the presence of chiral ligands.5a,c,6,7a In contrast, a single example of fused indoline-cyclobutane has been reported in its racemic form by Fagnou and co-workers.23 Using our optimized conditions, compounds 2aa and 2ab were obtained with high enantioselectivity (e.r. 97[thin space (1/6-em)]:[thin space (1/6-em)]3), albeit in low isolated yield due to significant competing proto-dehalogenation (Scheme 1c). Under the same conditions, the formation of cyclohexane-fused indoline 2ae was not observed. In contrast, chiral NHC ligands allowed the production of the same product in high yield and enantioselectivity.5a Overall, as shown with compounds 2aa–ab and 2ae, the current Pd/PCy3/BPA catalytic system does not seem to be sufficiently reactive to efficiently activate secondary C–H bonds.

The reaction of racemic substrate 1ac was also examined, in order to look for a possible kinetic resolution phenomenon (Scheme 2). With the same substrate and using a chiral NHC ligand, Kündig and co-workers observed a regiodivergent behavior, with each enantiomer of 1ac being transformed into a different enantioenriched product, 2ac or 2ad, resulting from the activation of the Me and Et group, respectively.5b Under our standard conditions, we observed only the formation of compound 2ac arising from the activation of the Me group, and an e.r. of 73[thin space (1/6-em)]:[thin space (1/6-em)]27 was measured at 39% conversion (s = 3.6).24 Hence, these two different chiral systems show a different behavior, with the chiral BPA giving rise to modest kinetic resolution.

image file: c6sc04006c-s2.tif
Scheme 2 Study of the kinetic resolution of a racemic substrate.

Finally, the methyl carbamate in indolines containing a tri- (2a) or tetrasubstituted (2u) stereocenter could be cleaved upon treatment with trimethylsilyl iodide,25 thus leading to valuable scalemic secondary amines 4a and 4u (Scheme 3). The latter were derivatized as ferrocenecarboxamides, according to our recently published method,8b to give amides 5a and 5u in excellent overall yield. The crystal structures of the corresponding major enantiomers were solved using X-ray diffraction analysis,26 thereby allowing us to independently confirm the S configuration of 2a6,27 and to ascribe the S configuration for 2u.18

image file: c6sc04006c-s3.tif
Scheme 3 Cleavage of the carbamate group and determination of absolute configurations. Reaction conditions: (1) (i) TMSI (10 equiv.), CHCl3, reflux; (ii) MeOH, reflux (only for 4u); and (2) for 5a: FcCOCl (1.1 equiv.), i-Pr2NEt (3 equiv.), 4-dimethylaminopyridine (0.1 equiv.), CH2Cl2, 0 → 20 °C, 83% for 2 steps; for 5u: LiN(SiMe3)2 (1.2 equiv.), FcCOCl (1.2 equiv.), THF, −78 → −10 °C, 80% for 2 steps. TMSI = trimethylsilyl iodide; Fc = ferrocene. a Thermal ellipsoids at the 30% probability level, most H atoms are omitted for clarity.26


In conclusion, we have reported the first highly enantioselective and efficient palladium(0)-catalyzed C(sp3)–H activation reaction using a chiral catalytic base instead of a chiral ancillary ligand. A fine tuning of both the BPA catalyst and the reaction solvent was key to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters. Further applications of this concept will be reported in due course.


This work was financially supported by the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007–2013/ under REA grant agreement no. 623605, and by the University of Basel. We thank Dr Eric Clot, Université Montpellier 2, for DFT calculations.

Notes and references

  1. Selected reviews: (a) R. Jazzar, J. Hitce, A. Renaudat, J. Sofack-Kreutzer and O. Baudoin, Chem.–Eur. J., 2010, 16, 2654 CrossRef CAS PubMed; (b) O. Baudoin, Chem. Soc. Rev., 2011, 40, 4902 RSC; (c) H. Li, B.-J. Li and Z.-J. Shi, Catal. Sci. Technol., 2011, 1, 191 RSC; (d) N. Dastbaravardeh, M. Christakakou, M. Haider and M. Schnürch, Synthesis, 2014, 46, 1421 CrossRef; (e) J. F. Hartwig, J. Am. Chem. Soc., 2016, 138, 2 CrossRef CAS PubMed.
  2. O. Baudoin, in Catalytic Transformations via C–H Activation, ed. J.-Q. Yu, Science of Synthesis, Georg Thieme Verlag KG, Stuttgart-New York, 2015, vol. 2, pp. 37–62 Search PubMed.
  3. Selected examples: (a) O. Baudoin, A. Herrbach and F. Guéritte, Angew. Chem., Int. Ed., 2003, 42, 5736 CrossRef CAS PubMed; (b) M. Chaumontet, R. Piccardi, N. Audic, J. Hitce, J.-L. Peglion, E. Clot and O. Baudoin, J. Am. Chem. Soc., 2008, 130, 15157 CrossRef CAS PubMed; (c) S. Rousseaux, M. Davi, J. Sofack-Kreutzer, C. Pierre, C. E. Kefalidis, E. Clot, K. Fagnou and O. Baudoin, J. Am. Chem. Soc., 2010, 132, 10706 CrossRef CAS PubMed; (d) J. Sofack-Kreutzer, N. Martin, A. Renaudat, R. Jazzar and O. Baudoin, Angew. Chem., Int. Ed., 2012, 51, 10399 CrossRef CAS PubMed; (e) S. Janody, R. Jazzar, A. Comte, P. M. Holstein, J.-P. Vors, M. J. Ford and O. Baudoin, Chem.–Eur. J., 2014, 20, 11084 CrossRef CAS PubMed; (f) D. Dailler, G. Danoun and O. Baudoin, Angew. Chem., Int. Ed., 2015, 54, 4919 CrossRef CAS PubMed; (g) P. M. Holstein, D. Dailler, J. Vantourout, J. Shaya and O. Baudoin, Angew. Chem., Int. Ed., 2016, 55, 2805 CrossRef CAS PubMed.
  4. For pioneering work: (a) G. Dyker, Angew. Chem., Int. Ed. Engl., 1992, 31, 1023 CrossRef; (b) G. Dyker, Angew. Chem., Int. Ed. Engl., 1994, 33, 103 CrossRef; (c) M. Catellani, E. Motti and S. Ghelli, Chem. Commun., 2000, 2003 RSC; other selected references: (d) C.-G. Dong and Q.-S. Hu, Angew. Chem., Int. Ed., 2006, 45, 2289 CrossRef CAS PubMed; (e) H. Ren and P. Knochel, Angew. Chem., Int. Ed., 2006, 45, 3462 CrossRef CAS PubMed; (f) M. Lafrance, S. I. Gorelsky and K. Fagnou, J. Am. Chem. Soc., 2007, 129, 14570 CrossRef CAS PubMed; (g) T. Watanabe, S. Oishi, N. Fujii and H. Ohno, Org. Lett., 2008, 10, 1759 CrossRef CAS PubMed; (h) S. Rousseaux, S. I. Gorelsky, B. K. W. Chung and K. Fagnou, J. Am. Chem. Soc., 2010, 132, 10692 CrossRef CAS PubMed; (i) C. Tsukano, M. Okuno and Y. Takemoto, Angew. Chem., Int. Ed., 2012, 51, 2763 CrossRef CAS PubMed; (j) T. Piou, L. Neuville and J. Zhu, Angew. Chem., Int. Ed., 2012, 51, 11561 CrossRef CAS PubMed; (k) J.-X. Yan, H. Li, X.-W. Liu, J.-L. Shi, X. Wang and Z.-J. Shi, Angew. Chem., Int. Ed., 2014, 53, 4945 CrossRef CAS PubMed.
  5. (a) M. Nakanishi, D. Katayev, C. Besnard and E. P. Kündig, Angew. Chem., Int. Ed., 2011, 50, 7438 CrossRef CAS PubMed; (b) D. Katayev, M. Nakanishi, T. Bürgi and E. P. Kündig, Chem. Sci., 2012, 3, 1422 RSC; (c) E. Larionov, M. Nakanishi, D. Katayev, C. Besnard and E. P. Kündig, Chem. Sci., 2013, 4, 1995 RSC; (d) D. Katayev, E. Larionov, M. Nakanishi, C. Besnard and E. P. Kündig, Chem.–Eur. J., 2014, 20, 15021 CrossRef CAS PubMed.
  6. S. Anas, A. Cordi and H. B. Kagan, Chem. Commun., 2011, 47, 11483 RSC.
  7. (a) T. Saget, S. J. Lemouzy and N. Cramer, Angew. Chem., Int. Ed., 2012, 51, 2238 CrossRef CAS PubMed; for the asymmetric synthesis of other fused ring systems, see: (b) T. Saget and N. Cramer, Angew. Chem., Int. Ed., 2012, 51, 12842 CrossRef CAS PubMed; (c) J. Pedroni, M. Boghi, T. Saget and N. Cramer, Angew. Chem., Int. Ed., 2014, 53, 9064 CrossRef CAS PubMed; (d) J. Pedroni, T. Saget, P. A. Donets and N. Cramer, Chem. Sci., 2015, 6, 5164 RSC; (e) J. Pedroni and N. Cramer, Angew. Chem., Int. Ed., 2015, 54, 11826 CrossRef CAS PubMed.
  8. (a) N. Martin, C. Pierre, M. Davi, R. Jazzar and O. Baudoin, Chem.–Eur. J., 2012, 18, 4480 CrossRef CAS PubMed; (b) P. M. Holstein, M. Vogler, P. Larini, G. Pilet, E. Clot and O. Baudoin, ACS Catal., 2015, 5, 4300 CrossRef CAS.
  9. L. Ackermann, Chem. Rev., 2011, 111, 1315 CrossRef CAS PubMed.
  10. C. E. Kefalidis, O. Baudoin and E. Clot, Dalton Trans., 2010, 39, 10528 RSC.
  11. In addition, a cooperative effect was demonstrated using a monoprotected tert-leucine and a chiral phosphine.7a.
  12. For pioneering work with chiral monoprotected aminoacids in asymmetric PdII-catalyzed C–H functionalization: (a) B.-F. Shi, N. Maugel, Y.-H. Zhang and J.-Q. Yu, Angew. Chem., Int. Ed., 2008, 47, 4882 CrossRef CAS PubMed; for an account: (b) K. M. Engle and J.-Q. Yu, J. Org. Chem., 2013, 78, 8927 CrossRef CAS PubMed.
  13. Selected examples: (a) H. Alper and N. Hamel, J. Am. Chem. Soc., 1990, 112, 2803 CrossRef CAS; (b) S. Mukherjee and B. List, J. Am. Chem. Soc., 2007, 129, 11336 CrossRef CAS PubMed; (c) G. Jiang, R. Halder, Y. Fang and B. List, Angew. Chem., Int. Ed., 2011, 50, 9752 CrossRef CAS PubMed; (d) Z. Chai and T. J. Rainey, J. Am. Chem. Soc., 2012, 134, 3615 CrossRef CAS PubMed; (e) K. Ohmatsu, M. Ito, T. Kunieda and T. Ooi, Nat. Chem., 2012, 4, 473 CrossRef CAS PubMed; (f) S.-Y. Yu, H. Zhang, Y. Gao, L. Mo, S. Wang and Z.-J. Yao, J. Am. Chem. Soc., 2013, 135, 11402 CrossRef CAS PubMed; (g) D. Zhang, H. Qiu, L. Jiang, F. Lv, C. Ma and W. Hu, Angew. Chem., Int. Ed., 2013, 52, 13356 CrossRef CAS PubMed; (h) P.-S. Wang, H.-C. Lin, Y.-J. Zhai, Z.-Y. Han and L.-Z. Gong, Angew. Chem., Int. Ed., 2014, 53, 12218 CrossRef CAS PubMed; (i) D. Banerjee, K. Junge and M. Beller, Angew. Chem., Int. Ed., 2014, 53, 13049 CrossRef CAS PubMed; (j) T. Jiang, T. Bartholomeyzik, J. Mazuela, J. Willersinn and J.-E. Bäckvall, Angew. Chem., Int. Ed., 2015, 54, 6024 CrossRef CAS PubMed; (k) H. M. Nelson, B. D. Williams, J. Miró and F. D. Toste, J. Am. Chem. Soc., 2015, 137, 3213 CrossRef CAS PubMed.
  14. For reviews: (a) R. J. Philipps, G. L. Hamilton and F. D. Toste, Nat. Chem., 2012, 4, 603 CrossRef PubMed; (b) M. Mahlau and B. List, Angew. Chem., Int. Ed., 2013, 52, 518 CrossRef CAS PubMed; (c) S. M. Inamdar, V. S. Shinde and N. T. Patil, Org. Biomol. Chem., 2015, 13, 8116 RSC.
  15. S.-B. Yan, S. Zhang and W.-L. Duan, Org. Lett., 2015, 17, 2458 CrossRef CAS PubMed.
  16. E.r. 75[thin space (1/6-em)]:[thin space (1/6-em)]25, 47% yield for indoline 2a, and e.r. 83.5[thin space (1/6-em)]:[thin space (1/6-em)]16.5, 39% yield for indoline 2ae: S. Zhang, J. Lu, J. Ye and W.-L. Duan, Chin. J. Org. Chem., 2016, 36, 752 CrossRef CAS.
  17. (a) T. Akiyama, J. Itoh, K. Yokota and K. Fuchibe, Angew. Chem., Int. Ed., 2004, 43, 1566 CrossRef CAS PubMed; (b) D. Uraguchi and M. Terada, J. Am. Chem. Soc., 2004, 126, 5356 CrossRef CAS PubMed; review: (c) D. Kampen, C. M. Reisinger and B. List, Top. Curr. Chem., 2009, 291, 395 CrossRef.
  18. See the ESI for details..
  19. (a) T. Akiyama, H. Morita, J. Itoh and K. Fuchibe, Org. Lett., 2005, 7, 2583 CrossRef CAS PubMed; (b) M. Rueping, E. Sugiono, C. Azap, T. Theissmann and M. Bolte, Org. Lett., 2005, 7, 3781 CrossRef CAS PubMed.
  20. K. Kaupmees, N. Tolstoluzhsky, S. Raja, M. Rueping and I. Leito, Angew. Chem., Int. Ed., 2013, 52, 11569 CrossRef CAS PubMed.
  21. With Me-Duphos: 97% yield, e.r. 96.5[thin space (1/6-em)]:[thin space (1/6-em)]3.5;6 with a chiral NHC: 86% yield, e.r. 95[thin space (1/6-em)]:[thin space (1/6-em)]5.5b.
  22. (a) E. J. Corey, R. J. McCaully and H. S. Sachdev, J. Am. Chem. Soc., 1970, 92, 2476 CrossRef CAS PubMed. For the enantioselective synthesis of tetrasubstituted indolines via other approaches: (b) F. Zhou, J. Guo, J. Liu, K. Ding, S. Yu and Q. Cai, J. Am. Chem. Soc., 2012, 134, 14326 CrossRef CAS PubMed; (c) Q. Cai and F. Zhou, Synlett, 2013, 408 CAS; (d) J. Liu, J. Yan, D. Qin and Q. Cai, Synthesis, 2014, 1917 Search PubMed; (e) Y. Miyazaki, N. Ohta, K. Semba and Y. Nakao, J. Am. Chem. Soc., 2014, 136, 3732 CrossRef CAS PubMed.
  23. S. Rousseaux, B. Liégault and K. Fagnou, Chem. Sci., 2012, 3, 244 RSC.
  24. Selectivity factor calculated as s = log[1 – c(1 + ee2ac)]/log[1 – c(1 – ee2ac)], where c = conversion of 1ac.
  25. M. E. Jung and M. A. Lyster, J. Chem. Soc., Chem. Commun., 1978, 315 RSC.
  26. CCDC 1486752 (5a) and 1486753 (5u) contain the supplementary crystallographic data for this paper..
  27. K. M. Bertini Gross, Y. M. Jun and P. Beak, J. Org. Chem., 1997, 62, 7679 CrossRef.


Electronic supplementary information (ESI) available: Full optimization tables, procedural, spectral and X-ray crystallographic (CIF) data, and DFT calculations. CCDC 1486752 and 1486753. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04006c

This journal is © The Royal Society of Chemistry 2016