Youai
Qiu
,
Bin
Yang
,
Can
Zhu
and
Jan-E.
Bäckvall
*
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91, Stockholm, Sweden. E-mail: jeb@organ.su.se
First published on 2nd September 2016
A highly selective olefin-assisted palladium-catalyzed oxidative carbocyclization via remote olefin insertion to afford cyclohexenes has been developed. It was shown that the assisting olefin moiety was indispensable for the formation of the cyclohexene product. Furthermore, preliminary studies on chiral anion-induced asymmetrical carbocyclization–borylation of enallenes have been carried out.
We recently reported on an olefin-directed palladium-catalyzed oxidative carbocyclization–borylation of allenes to cyclobutenes (Scheme 1a).5 In this reaction, the coordination of the olefin in Int-A triggers the allene attack on palladium,6 which results in the formation of Int-B. Subsequent olefin insertion to form a cyclobutene intermediate Int-C, followed by transmetallation and reductive elimination afforded the borylated cyclobutene derivatives A.
On the basis of these observations, we were particularly interested in the involvement of an additional double bond in a carbocyclization (Scheme 1b). We envisioned that the olefin insertion of intermediate Int-1 could lead to intermediate Int-2, and that coordination of the additional olefin to palladium would lead to a second carbocyclization to form spirocyclic intermediate Int-3, which on reaction with B2pin2 would give B. Alternatively, Int-1 may undergo ligand exchange and olefin insertion to give Int-5, which can be quenched by either B2pin2 or ArB(OH)2 to give either 2 or 3, respectively (Scheme 1b).
Based on this concept, we initially chose a readily accessible 3,4-dienoate 1a as the standard substrate. When 1a bearing an extra olefin was treated with Pd(OAc)2 (5 mol%), B2pin2 (1.3 equiv.), and BQ (p-benzoquinone) (1.1 equiv.) in THF at room temperature for 12 h, the envisioned spirocyclic product B was not observed (Scheme 2). Interestingly, the cyclohexene product 2a was obtained in 76% yield instead. It is obvious that intermediate Int-2 was not formed from intermediate Int-1via olefin insertion as we had envisioned, but rather the ligand exchange, from proximal olefin to remote olefin occurred in Int-1 to produce Int-4. Subsequent olefin insertion7 to give cyclic intermediate Int-5 followed by B2pin2 quenching would produce 2a (Scheme 1b). During this transformation, the proximal olefin is acting as the assisting group for the generation of palladium intermediate Int-1, while the remote olefin participates in the carbocyclization (Scheme 1c). To the best of our knowledge,8–10 the formation of six-membered rings in palladium-catalyzed oxidative carbocyclization of enallenes via olefin exchange has been rarely reported.11
To demonstrate the necessity of the assisting olefin group, we first investigated comparative experiments with enallenes lacking the additional olefin (Scheme 3). When substrate 1f with an assisting olefin was allowed to react under the same reaction conditions as those in Scheme 2, the cyclohexene product 2f was formed in 70% yield (Scheme 3a). However, when substrate 1fb, lacking the additional double bond, was subjected to the reaction conditions of Scheme 2 the corresponding six-membered ring product 2fb was not formed; instead 1fb was recovered in 88% (Scheme 3b). Importantly, we also observed the exclusive formation of 2h in 68% yield from substrate 1h (Scheme 3c). We also examined the reaction of a malonate-tethered substrate 1l, but the envisioned product 2l was not observed (Scheme 3d). These comparative experiments indicate that the assisting olefin of the substrate is an indispensable group for the formation of the palladium intermediate Int-4.
With these inspiring results in hand, we began to optimize the reaction conditions (for details, see the ESI, Table S1†). Solvent screening showed that 1,2-dichloroethane was the best solvent, in which the yield of 2a was 91% (Table S1,† entry 7). Other solvents such as THF, MeCN, and 1,4-dioxane also gave good yields (Table S1,† entries 1, 5, and 6). When the amount of BQ was increased to 1.5 equivalents, the yield of 2a was decreased to 78% (Table S1,† entry 8). The use of 2,6-dimethyl-BQ instead of BQ, gave a lower yield (Table S1,† entry 9). Catalyst screening showed that Pd(TFA)2 (TFA = trifluoroacetate) produced the corresponding cyclohexene derivative in only 36% yield together with 34% starting material recovered (Table S1,† entry 10).
The substrate scope for the formation of cyclohexene boron compounds 212,13 was then studied under the optimized reaction conditions (Scheme 4): in addition to methyl substituents on the enallene moiety, cyclobutylidene, cyclopentylidene, and cyclohexylidene enallenes (1b, 1c, and 1d) also gave the corresponding products 2b, 2c, and 2d in good yields. To our delight, enallenes with functional groups, such as free hydroxyl in 1e and imide in lk, furnished cyclohexene derivatives 2e and 2k in 83% and 76% yield. Furthermore, the reaction tolerates R to be different alkyl groups in this reaction, e.g. n-butyl (1f), or benzyl (1g).14 It is worth noting that the product 2h was exclusively obtained in 84% yield. Finally, the reaction of a dissymmetric allene 1i, bearing Me and phenyl, or 1j, bearing Me and i-Pr, afforded 2i in 86% yield, and 2j and 2j′ in 60% yield, respectively. The ratio of 2j and 2j′ was 1:2 due to the selective C–H bond cleavage, which occurred during allene attack forming Int-1 (see Scheme 1b). Notably, the reaction could be easily extended to a scale of 4.5 mmol of 1a (1.053 g) to afford the corresponding cyclohexene compound 2a (1.551 g, 90% yield).
After realization of the borylative carbocyclization, we next turned our attention to the arylating carbocyclization of enallenes. We were pleased to find that the arylative products15 could be obtained in good yields with a catalyst loading of 2 mol% Pd(OAc)2 (Scheme 5). The reaction of substrates with two methyls, cyclopentylidene, and cyclohexylidene, afforded the corresponding product 3a, 3c, and 3d in good yields. Interestingly, the substrate containing a free hydroxyl group could also be employed. Different alkyl substituents on the starting materials, such as n-butyl, benzyl, and 4-pentenyl groups were tolerated (3f–h). We also examined the scope of arylboronic acids, and electron-donating substituents such as 3-Me, and 3-MeO reacted smoothly under the standard conditions in good yields. Notably, the procedure tolerates a range of additional functional groups on the arylboronic acid, including bromo (3ad), vinyl (3ae), formyl (3af), and acetyl (3ag) groups, which is useful for further functionalization. Finally, it is worth noting that 2-naphthylboronic acid and 1-naphthylboronic acid also worked well, affording 3ah and 3ai in 84% and 55% yield, respectively.
Interestingly, this new olefin-assisting strategy could also be applied to an oxidative carbonylating carbocyclization9c,f,g for the preparation of cyclohexene esters (Scheme 6).16 When the substrate 1a was treated with Pd(OAc)2 (2 mol%), and BQ (1.1 equiv.) under carbon monoxide (1 atm) in methanol at room temperature for 12 h the carbonylation product 4a was formed in 82% yield (Scheme 6). Under the optimal reaction conditions, cyclopentylidene and cyclohexylidene substrates 1c and 1d afforded 4c and 4d, respectively in good yields. The substrate bearing the free hydroxyl group (1e) also worked well. Different allenes with alkyl substituents such as n-butyl, benzyl, and 4-pentenyl group, were also tested and worked well in this reaction. The reaction of a dissymmetric allene 1i, bearing Me and phenyl, afforded 4i in 70% yield. Finally, the scope of the alcohol partners in the carbocyclization carbonylation reaction was explored, and in addition to MeOH, ethanol and isopropanol were shown to react smoothly to provide the desired esters in good yield.
The biomimetic approach with the use of electron-transfer mediators (ETMs) is known to decrease the kinetic barrier for the reoxidation.17 In this aerobic approach the high kinetic barrier will be divided into several smaller units, and catalytic amounts of oxidant (BQ) would be enough to realize these transformations. When the reaction of 1a was treated with B2pin2 (1.3 equiv.), BQ (20 mol%), Pd(OAc)2 (5 mol%), and cobalt(salophen) (5 mol%) in the presence of O2 (1 atm), borylated product 2a was obtained in 89% yield. Phenylated product 3a was provided in 86% yield when PhB(OH)2 was used in place of B2pin2 (Scheme 7).
Preliminary attempt to develop an enantioselective carbocyclization–borylation of enallenes revealed that a reasonably good er value (83:17) was observed in the presence of catalytic amounts of Pd(OAc)2 and biphenol-type phosphoric acid C9d while poor enantiocontrol (55:45 er) was obtained with VAPOL phosphoric acid (Scheme 8).18,19
Based on the experiments in Scheme 3 and the reaction outcome, a possible mechanism for the olefin-assisted palladium-catalyzed oxidative carbocyclization of enallenes via remote olefin insertion is given in Scheme 9. The reaction of palladium with enallene 1 bearing the assisting olefin forms vinylpalladium intermediate Int-1via allene attack involving allenic C–H bond cleavage, which is promoted by the coordination of allene and the assisting olefin to Pd(II).5,6 Then, the vinylpalladium intermediate Int-4 would be generated from Int-1via ligand exchange (from proximal olefin to remote olefin), instead of a direct olefin insertion to form cyclobutene complex Int-2.5 Intermediate Int-4 would undergo a remote olefin insertion to give cyclic intermediate Int-5. Subsequent transmetallation of Int-5 with B2pin2 or arylboronic acid, followed by reductive elimination would give the target cyclohexene derivatives 2 or 3. Under CO pressure in alcohol, Int-5 can undergo an alkoxy-carbonylation to provide product 4.
Footnote |
† Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc02660e |
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