K.
Eichstaedt
a,
B.
Wicher
b,
M.
Gdaniec
c and
T.
Połoński
*a
aDepartment of Chemistry, Technical University, 80-233 Gdańsk, Poland. E-mail: tadpolon@pg.gda.pl
bDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, 60-780 Poznań, Poland
cFaculty of Chemistry, Adam Mickiewicz University, 61-614 Poznań, Poland. E-mail: magdan@amu.edu.pl
First published on 1st July 2016
Two crystalline supramolecular polypseudorotaxanes were obtained by combining permethylated pillar[5]arene as a macrocyclic wheel with 1,4-bis(1-imidazolyl)butane and 1,4-bis(iodoethynyl)benzene or 1,4-diiodo-1,3-butadiyne linked by C–I⋯N halogen bonds and creating a polyrotaxane axis. The resulting highly ordered supramolecular arrays were characterized by X-ray crystallography.
In this paper, we report the synthesis and structural characterization of two crystalline supramolecular polypseudorotaxanes by combining permethylated pillar[5]arene (MeP5A) as a macrocyclic wheel with 1,4-bis(1-imidazolyl)butane (1) and 1,4-bis(iodoethynyl)benzene (2) or 1,4-diiodo-1,3-butadiyne (3) linked by halogen bonds and creating a polyrotaxane axis. Pillararenes, a new family of macrocyclic hosts, due to their symmetrical structure and rigid electron-rich cavity are ideal candidates as host molecules for the construction of rotaxanes or pseudorotaxanes and the research interest in this class of compounds has grown rapidly.9 The facile preparation and excellent binding abilities of peralkylated pillararenes towards neutral guest molecules in organic solvents make them superior to water soluble cyclodextrins or cucurbiturils, possessing nearly the same cavity sizes as the host molecules for the fabrication of new supramolecular architectures. Thus we selected MeP5A as a host and bisimidazolyl derivative 1 as a guest due to their reported high association constant in nonpolar solvents [Ka of (4.7 ± 0.3) × 103 M−1].10 The encapsulated by multiple C–H⋯π and C–H⋯O interactions molecule of 1 possessing two unscreened imidazole nitrogen atoms should be able to further interact with halogen bond donors 2 or 3 and create a polymeric rotaxane axis. Halogen bonding has promising potential in supramolecular chemistry, particularly, as a design element in crystal engineering and molecular recognition.11 Heavier halogens, due to an anisotropic distribution of electrostatic potential, exhibit electrophilic characteristics and can interact with electron-pair donating heteroatoms (O, N, S) or anions. Since iodine atoms connected to C(sp) atoms form the strongest halogen bonds12 the iodoalkynes 2 and 3 were chosen as components of the polypseudorotaxane axis. Furthermore, due to a lesser steric overcrowding they are better accessible to the imidazole nitrogen atoms of 1 than the iodine atoms in fluorinated iodobenzenes, most frequently used as halogen bond donors.13 Obtaining three component co-crystals with predictable connectivity is obviously an extremely difficult task.14 Indeed, our initial attempt to crystallize an equimolar mixture of MeP5A, 1 and 2 afforded only a binary complex 1·2 composed of infinite chains of the halogen bonded components. However, preparation of pseudorotaxane MeP5A·1 from equimolar amounts of MeP5A and 1 in toluene–chloroform followed by its cocrystallization with 2 from the 1:2 mixture of tetrachloromethane and dichloromethane gave solvated crystals of the polypseudorotaxane MeP5A·1·2·(CCl4)2. The second ternary complex MeP5A·1·3·(toluene)1.5 was obtained in an analogous way (Fig. 2).‡
Triclinic crystals of MeP5A·1·2§ and MeP5A·1·3¶ contain infinite chains of alternating 1 and 2 or 1 and 3 molecules, respectively, connected by halogen bonds forming the polypseudorotaxane axis with the threaded pillararene MeP5A beads (Fig. 1). The halogen bonds connecting 1 with 2 or 1 with 3 are nearly linear (the C–I⋯N angles are 172°) and quite strong as evidenced by the I⋯N distances of 2.734–2.794 Å (77–79% of the sum of the van der Waals radii of I and N).15 The diimidazolylbutane unit 1 is accommodated centrally within the macrocycle with the MeP5A mean plane passing through the middle of the aliphatic (CH2)4 chain. Nevertheless the conformation of 1 differs in the two crystal structures: in MeP5A·1·2 the aliphatic chain of 1 adopts a folded conformation, whereas in MeP5A·1·3 it is fully extended.||
It is noteworthy that pillararene molecules assume a planar chiral conformation and their racemization occurs by rotation of the hydroquinone units.9a,16 Obviously, the synthesized pillar[5]arenes are racemic mixtures. Thus a close inspection of the structure of MeP5A·1·2 reveals that the polyrotaxane thread is composed of alternating pR and pS enantiomers of the MeP5A units. Furthermore, the pillararene chirality induces chiral conformations of the included guest molecules of 1 (Fig. 3). In contrast, the MeP5A·1·2 threads are built from the homochiral MeP5A molecules and the neighboring threads contain the molecules of the opposite chirality.
Fig. 3 Molecular structures of polypseudorotaxanes MeP5A·1·2 (top) and MeP5A·1·3 (bottom) formed via halogen bonds. |
It should be emphasized that the above polypseudorotaxane structures exist only in the solid state and their dissolution simply results in their dissociation and disassembly. This is due to the relatively low association constants of iodoethynyl derivatives and halogen bond acceptors in solution.17 The only interaction between the components that occurs in solution is a complexation equilibrium between pillararene MeP5A and bisimidazole 1 that is reflected by the corresponding 1H and 13C NMR spectra (see the ESI†).9a
In summary, we have presented the first two polypseudorotaxanes containing pillararene beads self-assembled with use of halogen bonds. A key to the success of the self-assembly of three-component supermolecules was the high affinity of pillararene MeP5A towards diimidazolylbutane derivative 1 which allowed the formation of a relatively stable pseudorotaxane. In addition, the highly symmetrical structure of the pillararene and its solubility in organic solvents facilitated the manipulation and crystallization of the complexes with structural regularity. Our work has demonstrated that with use of crystal engineering methods highly ordered and predictable complex supramolecular arrays may be readily accessible in a relatively simple way.
Footnotes |
† Electronic supplementary information (ESI) available: Experimental details, geometry of halogen and hydrogen bonds and crystal structure of MeP5A·1·42. CCDC 1465200, 1465201 and 1469513 contain the supplementary crystallographic data for this paper. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ce01416j |
‡ X-Ray diffraction data were collected with an Oxford Diffraction Supernova diffractometer and processed with the CrysAlis software.18 The crystal structures were solved with SIR2004 (ref. 19) and refined by full-matrix least-squares with SHELXL-2014 (ref. 20) within Olex-2.21 Drawings were prepared with Mercury22 software. |
§ Crystal data for MeP5A·1·2: C45H50O10·C10H14N4·C10H4I2·2(CCl4) (M = 1626.65 g mol−1), crystal size 0.3 × 0.2 × 0.02 mm3, triclinic, space group P (no. 2), a = 12.6235(2) Å, b = 16.2250(4) Å, c = 18.6220(4) Å, α = 90.7497(18)°, β = 103.7900(18)°, γ = 102.4114(17)°, V = 3609.24(13) Å3, Z = 2, Dc = 1.497 g cm−3, μ(CuKα) = 10.036 mm−1, T = 130 K, Cu Kα radiation (λ = 1.54184 Å), 58888 reflections measured (9.84° ≤ 2Θ ≤ 149.008°), 14769 unique (Rint = 0.0590, Rsigma = 0.0489) which were used in all calculations. The final R1 was 0.0544 (I > 2σ(I)) and wR2 was 0.1513 (all data). One of the methoxy methyl groups and one of the imidazolyl groups were refined as disordered over two positions. |
¶ Crystal data for MeP5A·1·3: C45H50O10·C10H14N4·C4I2·1.5(C7H8) (M = 2762.28 g mol−1), crystal size 0.4 × 0.35 × 0.2 mm3, triclinic, space group P (no. 2), a = 11.6992(1) Å, b = 14.9802(2) Å, c = 20.2256(3) Å, α = 72.161(1)°, β = 83.489(1)°, γ = 73.806(1)°, V = 3238.85(7) Å3, Z = 2, Dc = 1.416 g cm−3, μ(CuKα) = 8.116 mm−1, T = 130 K, Cu Kα radiation (λ = 1.54184 Å), 80767 reflections measured (4.59° ≤ 2Θ ≤ 153.03°), 13528 unique (Rint = 0.0537, Rsigma = 0.0239) which were used in all calculations. The final R1 was 0.0359 (I > 2σ(I)) and wR2 was 0.0991 (all data). Both toluene molecules are disordered and one of them is disordered around an inversion center. |
|| Crystal data for MeP5A·1·42: C45H50O10·C10H14N4·2(C6F4I2)·2(H2O) (M = 1780.85 g mol−1): orthorhombic, space group Pbcn (no. 60), a = 20.04603(13) Å, b = 23.88917(14) Å, c = 14.22073(10) Å, V = 6810.07(8) Å3, Z = 4, Dc = 1.737 g cm−3, μ(CuKα) = 15.107 mm−1, T = 130 K, Cu Kα radiation (λ = 1.54184 Å), 66932 reflections measured (13.10° ≤ 2Θ ≤ 149.00°), 6952 unique (Rint = 0.0498, Rsigma = 0.0213) which were used in all calculations. The final R1 was 0.0460 (I > 2σ(I)) and wR2 was 0.1041 (all data). The molecule of 1 and one of the water molecules have half occupancy and are disordered over a twofold symmetry axis. |
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