Issue 33, 2016
From the journal:

Chemical Communications

An optimal hydrogen-bond surrogate for α-helices†

Stephen T. Joya  and  Paramjit S. Arora*a  

* Corresponding authors

a Department of Chemistry, New York University, New York, NY 10003, USA
E-mail: arora@nyu.edu

Abstract

Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize α-helices in diverse peptide sequences.

Graphical abstract: An optimal hydrogen-bond surrogate for α-helices

  • This article is part of the themed collection: Foldamers
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Article information

DOI
https://doi.org/10.1039/C6CC01104G
Article type
Communication
Submitted
03 Feb 2016
Accepted
21 Mar 2016
First published
05 Apr 2016

Chem. Commun., 2016,52, 5738-5741

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An optimal hydrogen-bond surrogate for α-helices

S. T. Joy and P. S. Arora, Chem. Commun., 2016, 52, 5738 DOI: 10.1039/C6CC01104G

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