Issue 42, 2016
From the journal:

Nanoscale

Cytosolic delivery of large proteins using nanoparticle-stabilized nanocapsules†

Rui Tang, ORCID logo ‡a   Ziwen Jiang, ORCID logo ‡a   Moumita Ray,a   Singyuk Houa  and  Vincent M. Rotello*a  

* Corresponding authors

a Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA
E-mail: rotello@chem.umass.edu
Fax: +1-413-545-4490
Tel: +1-413-545-2058

Abstract

We report an effective intracellular delivery strategy for proteins of high molecular weight using AuNP stabilized capsules. This strategy provides direct delivery to the cytosol, avoiding endosomal entrapment.

Graphical abstract: Cytosolic delivery of large proteins using nanoparticle-stabilized nanocapsules

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Article information

DOI
https://doi.org/10.1039/C6NR07162G
Article type
Communication
Submitted
09 Sep 2016
Accepted
07 Oct 2016
First published
11 Oct 2016

Nanoscale, 2016,8, 18038-18041

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Cytosolic delivery of large proteins using nanoparticle-stabilized nanocapsules

R. Tang, Z. Jiang, M. Ray, S. Hou and V. M. Rotello, Nanoscale, 2016, 8, 18038 DOI: 10.1039/C6NR07162G

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