Issue 46, 2016
From the journal:

CrystEngComm

Absolute asymmetric synthesis of a sanguinarine derivative through crystal–solution interactions†

Qi Zhang, ORCID logo ‡a   Lina Jia,‡a   Jian-Rong Wanga  and  Xuefeng Mei*a  

* Corresponding authors

a Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: xuefengmei@simm.ac.cn

Abstract

A new construction reaction for the absolute asymmetric synthesis of a sanguinarine derivative was realized by crystal–solution interactions. A stochastic outcome with high enantiomeric excess (ee%) values (up to 100%) was observed under cooling crystallization, while preferential chiral amplification was observed with Viedma ripening.

Graphical abstract: Absolute asymmetric synthesis of a sanguinarine derivative through crystal–solution interactions

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Article information

DOI
https://doi.org/10.1039/C6CE01765G
Article type
Communication
Submitted
12 Aug 2016
Accepted
29 Sep 2016
First published
29 Sep 2016

CrystEngComm, 2016,18, 8834-8837

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Absolute asymmetric synthesis of a sanguinarine derivative through crystal–solution interactions

Q. Zhang, L. Jia, J. Wang and X. Mei, CrystEngComm, 2016, 18, 8834 DOI: 10.1039/C6CE01765G

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