Issue 33, 2016
From the journal:

Analytical Methods

Paper-based sperm DNA integrity analysis†

Reza Nosrati,‡a   Max M. Gong,‡a   Maria C. San Gabriel,b   Armand Zinib  and  David Sinton*a  

* Corresponding authors

a Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Rd., Toronto, Ontario, Canada
E-mail: sinton@mie.utoronto.ca
Tel: +1 416 978 1623

b Urology Research Laboratory, Department of Surgery, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada

Abstract

We demonstrate a rapid, sensitive, and low cost paper-based approach for sperm chromatin integrity analysis that quantifies both DNA fragmentation and packaging. The paper-based test provides identical clinical outcome as the gold standard sperm chromatin structure assay. This technology is fast, simple, and suitable for broad application in clinics.

Graphical abstract: Paper-based sperm DNA integrity analysis

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Article information

DOI
https://doi.org/10.1039/C6AY01506A
Article type
Communication
Submitted
25 May 2016
Accepted
20 Jul 2016
First published
26 Jul 2016

Anal. Methods, 2016,8, 6260-6264

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Paper-based sperm DNA integrity analysis

R. Nosrati, M. M. Gong, M. C. San Gabriel, A. Zini and D. Sinton, Anal. Methods, 2016, 8, 6260 DOI: 10.1039/C6AY01506A

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