Issue 26, 2015

Perfluorobutyl iodide-assisted direct cyanomethylation of azoles and phenols with acetonitrile

Abstract

A perfluorobutyl iodide-assisted transition-metal-free cyanomethylation of azoles and phenols with acetonitrile in the presence of NaH has been developed. The reaction proceeded smoothly under mild reaction conditions to give the cyanomethylated products in moderate to high yields. A mechanism involving the cyanomethyl radical through C–H bond cleavage in acetonitrile was proposed.

Graphical abstract: Perfluorobutyl iodide-assisted direct cyanomethylation of azoles and phenols with acetonitrile

Supplementary files

Article information

Article type
Communication
Submitted
07 Jan 2015
Accepted
10 Feb 2015
First published
10 Feb 2015

RSC Adv., 2015,5, 20562-20565

Author version available

Perfluorobutyl iodide-assisted direct cyanomethylation of azoles and phenols with acetonitrile

J. Zhang, W. Wu, X. Ji and S. Cao, RSC Adv., 2015, 5, 20562 DOI: 10.1039/C5RA02242H

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