Issue 9, 2015
From the journal:

Chemical Communications

Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates†

Dongwon Shin,a   Peter Lönn,b   Steven F. Dowdyb  and  Yitzhak Tor*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, USA
E-mail: ytor@ucsd.edu

b Cellular & Molecular Medicine, University of California, San Diego, La Jolla, USA

Abstract

Singly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is tolerated well by the cellular silencing machinery.

Graphical abstract: Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates

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Article information

DOI
https://doi.org/10.1039/C4CC08809C
Article type
Communication
Submitted
05 Nov 2014
Accepted
05 Dec 2014
First published
05 Dec 2014

Chem. Commun., 2015,51, 1662-1665

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Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates

D. Shin, P. Lönn, S. F. Dowdy and Y. Tor, Chem. Commun., 2015, 51, 1662 DOI: 10.1039/C4CC08809C

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