Issue 59, 2015
From the journal:

Chemical Communications

A red-emitting ratiometric fluorescent probe based on a benzophosphole P-oxide scaffold for the detection of intracellular sodium ions†

Masayasu Taki,*a   Hiroaki Ogasawara,b   Hiroshi Osaki,b   Aiko Fukazawa,b   Yoshikatsu Sato,a   Kimi Ogasawara,c   Tetsuya Higashiyamaacd  and  Shigehiro Yamaguchi*ab  

* Corresponding authors

a Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo, Chikusa, Nagoya 464-8602, Japan
E-mail: taki@itbm.nagoya-u.ac.jp, yamaguchi@chem.naogya-u.ac.jp

b Department of Chemistry, Graduate School of Science, Nagoya University, Furo, Chikusa, Nagoya 464-8602, Japan

c JST ERATO Higashiyama Live-Holonics Project, Nagoya University, Furo, Chikusa, Nagoya 464-8602, Japan

d Division of Biological Science, Graduate School of Science, Nagoya University, Furo, Chikusa, Nagoya 464-8602, Japan

Abstract

We disclose the development of a ratiometric fluorescent probe based on a benzophosphole P-oxide and its application for the detection of intracellular Na+ ions. Excitation by visible light induced red emission from this probe in water, which was subjected to a hypsochromic shift upon complexation with Na+. Based on this change, a ratiometric analysis enabled us to visualise changes in the Na+ concentration in living mammalian cells.

Graphical abstract: A red-emitting ratiometric fluorescent probe based on a benzophosphole P-oxide scaffold for the detection of intracellular sodium ions

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Article information

DOI
https://doi.org/10.1039/C5CC03547C
Article type
Communication
Submitted
28 Apr 2015
Accepted
17 Jun 2015
First published
17 Jun 2015

Chem. Commun., 2015,51, 11880-11883

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A red-emitting ratiometric fluorescent probe based on a benzophosphole P-oxide scaffold for the detection of intracellular sodium ions

M. Taki, H. Ogasawara, H. Osaki, A. Fukazawa, Y. Sato, K. Ogasawara, T. Higashiyama and S. Yamaguchi, Chem. Commun., 2015, 51, 11880 DOI: 10.1039/C5CC03547C

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