Issue 6, 2014

Gold nanoparticle-based exonuclease III signal amplification for highly sensitive colorimetric detection of folate receptor

Abstract

By combining terminal protection of small molecule (folate)-capped DNA probes, exonuclease III signal amplification and gold nanoparticles, we developed a simple and label-free colorimetric assay for highly sensitive detection of folate receptor (FR). A detection limit of 50 fM FR was obtained using UV-vis spectrometry and 10 pM FR could be visualized by the naked eye.

Graphical abstract: Gold nanoparticle-based exonuclease III signal amplification for highly sensitive colorimetric detection of folate receptor

Supplementary files

Article information

Article type
Communication
Submitted
19 Nov 2013
Accepted
30 Dec 2013
First published
05 Feb 2014

Nanoscale, 2014,6, 3055-3058

Author version available

Gold nanoparticle-based exonuclease III signal amplification for highly sensitive colorimetric detection of folate receptor

X. Yang and Z. Gao, Nanoscale, 2014, 6, 3055 DOI: 10.1039/C3NR06139F

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