Issue 26, 2014

Altering physical properties of pharmaceutical co-crystals in a systematic manner

Abstract

Systematic structure–property studies on a series of co-crystals of potential cancer drugs with aliphatic dicarboxylic acids were undertaken. This study reveals that systematic changes to the molecular nature of the co-crystallizing agent combined with control over the way individual building blocks are organized within the crystalline lattice makes it possible to establish predictable links between molecular structure and macroscopic physical properties, such as melting behaviour and aqueous solubility. However, it is not possible to find any notable correlation between physical properties and chemical compositions in the absence of structural consistency.

Graphical abstract: Altering physical properties of pharmaceutical co-crystals in a systematic manner

Supplementary files

Article information

Article type
Paper
Submitted
26 Jan 2014
Accepted
05 Mar 2014
First published
05 Mar 2014

CrystEngComm, 2014,16, 5870-5877

Author version available

Altering physical properties of pharmaceutical co-crystals in a systematic manner

C. B. Aakeröy, S. Forbes and J. Desper, CrystEngComm, 2014, 16, 5870 DOI: 10.1039/C4CE00206G

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