Issue 91, 2014

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

Abstract

The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.

Graphical abstract: Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

Supplementary files

Article information

Article type
Communication
Submitted
04 Jul 2014
Accepted
18 Sep 2014
First published
19 Sep 2014

Chem. Commun., 2014,50, 14201-14204

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

A. Benjdia, K. Heil, A. Winkler, T. Carell and I. Schlichting, Chem. Commun., 2014, 50, 14201 DOI: 10.1039/C4CC05158K

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