Issue 46, 2013
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed reductive homocoupling of N′-tosyl arylhydrazines†

Jin-Biao Liu,a   Lin Nie,a   Hui Yan,a   Li-Hua Jiang,b   Jiang Wenga  and  Gui Lu*ac  

* Corresponding authors

a Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, P. R. China
E-mail: lugui@mail.sysu.edu.cn
Fax: (+86)-20-39943048

b School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, P. R. China

c Institute of Human Virology, Sun Yat-sen University, Guangzhou, P. R. China

Abstract

A novel procedure for the preparation of biaryl compounds by Pd-catalyzed homocoupling of N′-tosyl arylhydrazine has been described. N′-Tosyl arylhydrazine, as a readily available and stable coupling partner, demonstrated its generality in the homocoupling reactions. The scope of the reaction and possible mechanism have also been investigated.

Graphical abstract: Palladium-catalyzed reductive homocoupling of N′-tosyl arylhydrazines

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Article information

DOI
https://doi.org/10.1039/C3OB41546E
Article type
Communication
Submitted
28 Jul 2013
Accepted
10 Oct 2013
First published
11 Oct 2013

Org. Biomol. Chem., 2013,11, 8014-8017

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Palladium-catalyzed reductive homocoupling of N′-tosyl arylhydrazines

J. Liu, L. Nie, H. Yan, L. Jiang, J. Weng and G. Lu, Org. Biomol. Chem., 2013, 11, 8014 DOI: 10.1039/C3OB41546E

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