Issue 2, 2013
From the journal:

Natural Product Reports

Anticancer steroids: linking natural and semi-synthetic compounds†

Jorge A. R. Salvador,*ab   João F. S. Carvalho,b   Marco A. C. Neves,b   Samuel M. Silvestre,c   Alcino J. Leitão,ab   M. Manuel C. Silvaab  and  M. Luisa Sá e Melo*ab  

* Corresponding authors

a Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Polo das Ciências da Saúde, Coimbra, Portugal
E-mail: salvador@ci.uc.pt, samelo@ff.uc.pt
Tel: +351239488479

b CNC-Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal

c Health Sciences Research Center, Faculdade de Ciências da Saúde, Universidade da Beira Interior, 6201-506 Covilhã, Portugal

Abstract

Covering: up to 2012

Steroids, a widespread class of natural organic compounds occurring in animals, plants and fungi, have shown great therapeutic value for a broad array of pathologies. The present overview is focused on the anticancer activity of steroids, which is very representative of a rich structural molecular diversity and ability to interact with various biological targets and pathways. This review encompasses the most relevant discoveries on steroid anticancer drugs and leads through the last decade and comprises 668 references.

Graphical abstract: Anticancer steroids: linking natural and semi-synthetic compounds

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Article information

DOI
https://doi.org/10.1039/C2NP20082A
Article type
Review Article
Submitted
31 Jul 2012
First published
14 Nov 2012

Nat. Prod. Rep., 2013,30, 324-374

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Anticancer steroids: linking natural and semi-synthetic compounds

J. A. R. Salvador, J. F. S. Carvalho, M. A. C. Neves, S. M. Silvestre, A. J. Leitão, M. M. C. Silva and M. L. Sá e Melo, Nat. Prod. Rep., 2013, 30, 324 DOI: 10.1039/C2NP20082A

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