Issue 10, 2012
From the journal:

Natural Product Reports

The impact of structural biology on alkaloid biosynthesis research†

Santosh Panjikar,*ab   Joachim Stoeckigt,c   Sarah O'Connord  and  Heribert Warzechae  

* Corresponding authors

a Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168, Australia
E-mail: santosh.panjikar@synchrotron.org.au

b Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia

c Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, 388 Yu Hang Tang Road, Hangzhou, P. R. China
E-mail: joesto2000@yahoo.com

d John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
E-mail: Sarah.O'Connor@jic.ac.uk

e Technische Universität Darmstadt, Plant Biotechnology and Metabolic Engineering, Schnittspahnstrasse 3-5, 64287 Darmstadt, Germany
E-mail: warzecha@bio.tu-darmstadt.de

Abstract

Covering: 1997 to 2012

In the recent past, macromolecular crystallography has gone through substantial methodological and technological development. The purpose of this review is to provide a general overview of structural biology and its impact on enzyme structure/function analysis and illustrate how it is modifying the focus of research relevant to alkaloid biosynthesis.

Graphical abstract: The impact of structural biology on alkaloid biosynthesis research

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Article information

DOI
https://doi.org/10.1039/C2NP20057K
Article type
Review Article
Submitted
30 Apr 2012
First published
21 Aug 2012

Nat. Prod. Rep., 2012,29, 1176-1200

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The impact of structural biology on alkaloid biosynthesis research

S. Panjikar, J. Stoeckigt, S. O'Connor and H. Warzecha, Nat. Prod. Rep., 2012, 29, 1176 DOI: 10.1039/C2NP20057K

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