Issue 8, 2012

Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells

Abstract

Plant cells are characterized by the presence of chloroplasts, membrane lipids of which contain up to ∼80% mono- and digalactosyldiacylglycerol (MGDG and DGDG). The synthesis of MGDG in the chloroplast envelope is essential for the biogenesis and function of photosynthetic membranes, is coordinated with lipid metabolism in other cell compartments and is regulated in response to environmental factors. Phenotypic analyses of Arabidopsis using the recently developed specific inhibitor called galvestine-1 complete previous analyses performed using various approaches, from enzymology, cell biology to genetics. This review details how this probe could be beneficial to study the lipid homeostasis system at the whole cell level and highlights connections between MGDG synthesis and Arabidopsis flower development.

Graphical abstract: Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells

Article information

Article type
Review Article
Submitted
01 Mar 2012
Accepted
20 Apr 2012
First published
20 Apr 2012

Mol. BioSyst., 2012,8, 2023-2035

Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells

L. Boudière, C. Y. Botté, N. Saidani, M. Lajoie, J. Marion, L. Bréhélin, Y. Yamaryo-Botté, B. Satiat-Jeunemaître, C. Breton, A. Girard-Egrot, O. Bastien, J. Jouhet, D. Falconet, M. A. Block and E. Maréchal, Mol. BioSyst., 2012, 8, 2023 DOI: 10.1039/C2MB25067E

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