Issue 24, 2012
From the journal:

CrystEngComm

Pasteur revisited: chiral separation by crystallization on self-assembled monolayers†

Jie Chena  and  Allan S. Myerson*a  

* Corresponding authors

a Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue 66-568, Cambridge, MA 02139, USA
E-mail: myerson@mit.edu

Abstract

We revisited Pasteur's crystallization based chiral separation and obtained >90% pure L-glutamic acid by using a D-penicillamine self-assembled monolayer as the resolving auxiliary and manually removing enantiopure crystals identified through Raman microscopy. Identical conditions in bulk solutions yielded only racemic crystals.

Graphical abstract: Pasteur revisited: chiral separation by crystallization on self-assembled monolayers

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Article information

DOI
https://doi.org/10.1039/C2CE26415C
Article type
Communication
Submitted
31 Aug 2012
Accepted
03 Oct 2012
First published
09 Oct 2012

CrystEngComm, 2012,14, 8326-8329

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Pasteur revisited: chiral separation by crystallization on self-assembled monolayers

J. Chen and A. S. Myerson, CrystEngComm, 2012, 14, 8326 DOI: 10.1039/C2CE26415C

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