Issue 66, 2012

Combining piracetam and lithium salts: ionic co-crystals and co-drugs?

Abstract

Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.

Graphical abstract: Combining piracetam and lithium salts: ionic co-crystals and co-drugs?

Supplementary files

Article information

Article type
Communication
Submitted
29 May 2012
Accepted
25 Jun 2012
First published
26 Jun 2012

Chem. Commun., 2012,48, 8219-8221

Combining piracetam and lithium salts: ionic co-crystals and co-drugs?

D. Braga, F. Grepioni, L. Maini, D. Capucci, S. Nanna, J. Wouters, L. Aerts and L. Quéré, Chem. Commun., 2012, 48, 8219 DOI: 10.1039/C2CC33855F

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