Issue 57, 2012
From the journal:

Chemical Communications

A rapid and facile signal enhancement method for microcantilever-based immunoassays using the agglomeration of ferromagnetic nanoparticles†

Dongkyu Lee,a   Donghoon Kwon,a   Wooree Ko,a   Jinmyoung Joo,a   Hyejung Seo,b   Soo Suk Leeb  and  Sangmin Jeon*a  

* Corresponding authors

a Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea
E-mail: jeons@postech.ac.kr
Fax: +82-54-279-5528
Tel: +82-54-279-2392

b Samsung Advanced Institute of Technology (SAIT), Suwon, Korea

Abstract

A rapid and facile signal enhancement method for detecting alpha-fetoprotein (AFP) was developed using the magnetic agglomeration of ferromagnetic nanoparticles and microcantilever sensors. The resonance frequency and deflection of the cantilevers were found to be more than 10-fold greater than that before physical agglomeration of the free nanoparticles around the magnetized nanoparticles.

Graphical abstract: A rapid and facile signal enhancement method for microcantilever-based immunoassays using the agglomeration of ferromagnetic nanoparticles

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Article information

DOI
https://doi.org/10.1039/C2CC32400H
Article type
Communication
Submitted
03 Apr 2012
Accepted
30 May 2012
First published
31 May 2012

Chem. Commun., 2012,48, 7182-7184

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A rapid and facile signal enhancement method for microcantilever-based immunoassays using the agglomeration of ferromagnetic nanoparticles

D. Lee, D. Kwon, W. Ko, J. Joo, H. Seo, S. S. Lee and S. Jeon, Chem. Commun., 2012, 48, 7182 DOI: 10.1039/C2CC32400H

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