Issue 46, 2012
From the journal:

Chemical Communications

Enantioselective bromolactonization of cis-1,2-disubstituted olefinic acids using an amino-thiocarbamate catalyst†‡

Chong Kiat Tan,a   Chencheng Lea  and  Ying-Yeung Yeung*a  

* Corresponding authors

a Department of Chemistry, NUS, 3 Science Drive 3, Singapore, Singapore
E-mail: chmyyy@nus.edu.sg
Fax: +65-6779-1691
Tel: +65-6516-7760

Abstract

A facile, highly regio- and enantioselective amino-thiocarbamate-catalyzed bromolactonization of cis-1,2-disubstituted olefinic acids has been developed. The use of the enantio-enriched lactones in the synthesis of chiral synthetic intermediates is also demonstrated.

Graphical abstract: Enantioselective bromolactonization of cis-1,2-disubstituted olefinic acids using an amino-thiocarbamate catalyst

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Article information

DOI
https://doi.org/10.1039/C2CC31148H
Article type
Communication
Submitted
15 Feb 2012
Accepted
19 Mar 2012
First published
20 Mar 2012

Chem. Commun., 2012,48, 5793-5795

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Enantioselective bromolactonization of cis-1,2-disubstituted olefinic acids using an amino-thiocarbamate catalyst

C. K. Tan, C. Le and Y. Yeung, Chem. Commun., 2012, 48, 5793 DOI: 10.1039/C2CC31148H

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