Issue 31, 2012

Asymmetric synthesis of α-amino boronate esters via organocatalytic pinacolboryl addition to tosylaldimines

Abstract

Organocatalytic nucleophilic pinacolboryl addition from in situ generated MeO → B2pin2 to C[double bond, length as m-dash]N double bond can be performed enantioselectively with the aid of chiral phosphines, which promote enantiofacial differentiation in the course of the C–B bond formation.

Graphical abstract: Asymmetric synthesis of α-amino boronate esters via organocatalytic pinacolboryl addition to tosylaldimines

  • This article is part of the themed collection: Chirality

Article information

Article type
Communication
Submitted
02 Jan 2012
Accepted
16 Feb 2012
First published
17 Feb 2012

Chem. Commun., 2012,48, 3769-3771

Asymmetric synthesis of α-amino boronate esters via organocatalytic pinacolboryl addition to tosylaldimines

C. Solé, H. Gulyás and E. Fernández, Chem. Commun., 2012, 48, 3769 DOI: 10.1039/C2CC00020B

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