Issue 10, 2012

Effect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Abstract

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

Graphical abstract: Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Supplementary files

Article information

Article type
Communication
Submitted
02 Aug 2011
Accepted
07 Nov 2011
First published
23 Nov 2011

Chem. Commun., 2012,48, 1547-1549

Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Y. S. Y. Hsieh, D. Taleski, B. L. Wilkinson, L. C. Wijeyewickrema, T. E. Adams, R. N. Pike and R. J. Payne, Chem. Commun., 2012, 48, 1547 DOI: 10.1039/C1CC14773K

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