Issue 3, 2012
From the journal:

Journal of Materials Chemistry

Preparation of dopamine-modified boron nanoparticles

Zhe Gao,a   Nathan I. Walton,a   Alexander Malugin,bd   Hamidreza Ghandeharibcd  and  Ilya Zharov*ad  

* Corresponding authors

a Department of Chemistry, University of Utah, Salt Lake City, UT, USA
E-mail: i.zharov@utah.edu
Fax: +1 801 581 84333
Tel: +1 801 587 9335

b Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA
E-mail: hamid.ghandehari@pharm.utah.edu
Fax: +1 801 581 3674
Tel: +1 801 587 1566

c Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
E-mail: hamid.ghandehari@pharm.utah.edu
Fax: +1 801 585 5151
Tel: +1 801 587 1566

d Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, Utah, USA

Abstract

We developed a method to obtain water-dispersible boron nanoparticles (BNPs) as a potential boron delivery agent for cancer treatment. The 40 nm nanoparticles are prepared by mechanical milling in undecylenic acid followed by ligand exchange with dopamine. These particles can be rendered fluorescent by the attachment of a fluorophore to the primary amine of the dopamine, which could be used to locate the particles in a cell media. Dopamine-modified boron nanoparticles did not show signs of toxicity toward murine macrophage cells.

Graphical abstract: Preparation of dopamine-modified boron nanoparticles

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Article information

DOI
https://doi.org/10.1039/C1JM12655E
Article type
Paper
Submitted
09 Jun 2011
Accepted
06 Oct 2011
First published
11 Nov 2011

J. Mater. Chem., 2012,22, 877-882

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Preparation of dopamine-modified boron nanoparticles

Z. Gao, N. I. Walton, A. Malugin, H. Ghandehari and I. Zharov, J. Mater. Chem., 2012, 22, 877 DOI: 10.1039/C1JM12655E

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