Issue 39, 2011
From the journal:

Chemical Communications

A facile and sensitive immunoassay for the detection ofalpha-fetoprotein using gold-coated magnetic nanoparticleclusters and dynamic light scattering†

Changho Chun,‡a   Jinmyoung Joo,‡a   Donghoon Kwon,a   Chang Sup Kim,a   Hyung Joon Cha,a   Myung-Sub Chungb  and  Sangmin Jeon*a  

* Corresponding authors

a Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea
E-mail: jeons@postech.ac.kr
Fax: +82-54-279-5528
Tel: +82-54-279-2392

b Department of Food Science and Technology, Chung-Ang University, Anseong, Korea

Abstract

A facile and sensitive immunoassay protocol for the detection of alpha-fetoprotein (AFP) was developed using gold-coated iron oxide magnetic nanoclusters and dynamic light scattering (DLS) methods. The increase in the average particle size due to AFP-mediated aggregation was measured using DLS, and the detection limit was better than 0.01 ng mL−1.

Graphical abstract: A facile and sensitive immunoassay for the detection of alpha-fetoprotein using gold-coated magnetic nanoparticle clusters and dynamic light scattering

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Article information

DOI
https://doi.org/10.1039/C1CC14024H
Article type
Communication
Submitted
05 Jul 2011
Accepted
25 Aug 2011
First published
09 Sep 2011

Chem. Commun., 2011,47, 11047-11049

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A facile and sensitive immunoassay for the detection of alpha-fetoprotein using gold-coated magnetic nanoparticle clusters and dynamic light scattering

C. Chun, J. Joo, D. Kwon, C. S. Kim, H. J. Cha, M. Chung and S. Jeon, Chem. Commun., 2011, 47, 11047 DOI: 10.1039/C1CC14024H

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