Issue 32, 2011

The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities

Abstract

The synthesis of selenium analogues of de-O-sulfonated ponkoranol, a naturally occurring sulfonium-ion glucosidase inhibitor isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against two recombinant intestinal enzymes maltase glucoamylase (MGAM) and sucrase isomaltase (SI) are described.

Graphical abstract: The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities

Supplementary files

Article information

Article type
Communication
Submitted
24 May 2011
Accepted
28 Jun 2011
First published
13 Jul 2011

Chem. Commun., 2011,47, 9134-9136

The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities

R. Eskandari, K. Jones, D. R. Rose and B. M. Pinto, Chem. Commun., 2011, 47, 9134 DOI: 10.1039/C1CC13052H

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