Issue 41, 2010
From the journal:

Chemical Communications

The evolvability of lead peptides from small library screens†

Jinglei Zhang,ab   Berea A. R. Williams,ab   Mikael T. Nilssona  and  John C. Chaput*ab  

* Corresponding authors

a Center for Evolutionary Medicine and Informatics at the Biodesign Institute, Arizona State University, Tempe, USA
E-mail: john.chaput@asu.edu
Fax: +1 480-727-6947
Tel: +1 480-727-0392

b Department of Chemistry and Biochemistry, Arizona State University, Tempe, USA

Abstract

Very little is known about the evolvability of lead peptides that are isolated from small library screens. Here we begin to explore this question by comparing the directed evolution of two peptides previously isolated from a small library screen to new ligands generated de novo by in vitro selection.

Graphical abstract: The evolvability of lead peptides from small library screens

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0CC01475C
Article type
Communication
Submitted
18 May 2010
Accepted
11 Aug 2010
First published
09 Sep 2010

Chem. Commun., 2010,46, 7778-7780

Permissions

Request permissions

The evolvability of lead peptides from small library screens

J. Zhang, B. A. R. Williams, M. T. Nilsson and J. C. Chaput, Chem. Commun., 2010, 46, 7778 DOI: 10.1039/C0CC01475C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements