Novel and efficient MR active aqueous colloidal Fe3O4 nanoassemblies

K. C. Barick; M. Aslam; Yen-Po Lin; D. Bahadur; Pottumarthi V. Prasad; Vinayak P. Dravid

doi:10.1039/B911626E

Novel and efficient MR active aqueous colloidal Fe₃O₄ nanoassemblies†

K. C. Barick,^a M. Aslam,*^b Yen-Po Lin,^c D. Bahadur,*^a Pottumarthi V. Prasad^d and Vinayak P. Dravid*^c

* Corresponding authors

^a Dept. of Metallurgical Engineering & Materials Science, Indian Institute of Technology Bombay, India
E-mail: dhirenb@iitb.ac.in
Fax: +91-22-2576 3480
Tel: +91-22-25767632

^b Dept. of Physics, Indian Institute of Technology Bombay, India
E-mail: m.aslam@iitb.ac.in
Fax: +91-22-2576 3480
Tel: +91-22-25767585

^c Dept. of Materials Science & Engineering, International Institute for Nanotechnology, Northwestern University, Evanston, Illinois, USA
E-mail: v-dravid@northwestern.edu
Fax: +1-847-467-6573
Tel: +1-847-467-1363

^d Dept. of Radiology, Evanston Northwestern Healthcare, Evanston, Illinois, USA

Abstract

This work demonstrates a new class of magnetic resonance (MR) active aqueous Fe₃O₄ magnetic nanoparticle nanoassemblies (Fe₃O₄ MNNA) of ∼40 nm size comprising ∼6 nm particles. They exhibit enhancement in T₂ MR contrast as compared to 6 nm isolated counterparts (Fe₃O₄MNP) and commercial contrast agent, ferumoxytol. This significant improvement in the T₂ MR signal arises from the synergistic magnetism of multiple Fe₃O₄nanoparticles assembled in Fe₃O₄ MNNA. These nanoassemblies also show better colloidal stability, higher magnetization, good specific absorption rate (under external AC magnetic field) and cytocompatibility with cells. Further, the functional groups (–NH₂) present on the surface of Fe₃O₄ particles can be accessible for routine conjugation of biomolecules through well-developed bioconjugation chemistry. Specifically, a new MR active colloidal amine-functionalized Fe₃O₄ nanoassembly with enhanced T₂ contrast properties has been fabricated, which can also be used as an effective heating source for hyperthermia treatment of cancer.

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Article information

DOI: https://doi.org/10.1039/B911626E
Article type: Paper
Submitted: 15 Jun 2009
Accepted: 16 Jul 2009
First published: 11 Aug 2009

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J. Mater. Chem., 2009,19, 7023-7029

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Novel and efficient MR active aqueous colloidal Fe₃O₄ nanoassemblies

K. C. Barick, M. Aslam, Y. Lin, D. Bahadur, P. V. Prasad and V. P. Dravid, J. Mater. Chem., 2009, 19, 7023 DOI: 10.1039/B911626E

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Journal of Materials Chemistry