Issue 7, 2009
From the journal:

CrystEngComm

Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure†

Francesca P. A. Fabbiani,*a   Birger Dittrich,b   Alastair J. Florence,c   Thomas Gelbrich,d   Michael B. Hursthouse,e   Werner F. Kuhs,a   Norman Shanklandc  and  Heidrun Sowaa  

* Corresponding authors

a Georg August Universität Göttingen, GZG, Abteilung Kristallographie, Göttingen, Germany
E-mail: ffabbia@gwdg.de
Fax: +49 551 399521
Tel: +49 551 393935

b Georg August Universität Göttingen Institut für Anorganische Chemie, Göttingen, Germany

c Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow, UK

d Institut für Pharmazie, Universität Innsbruck, Josef-Moeller-Haus, Innrain 52c, Innsbruck, Austria

e School of Chemistry, University of Southampton, Highfield, Southampton, UK

Abstract

Two novel sodium salts of the antibiotic ciprofloxacin were crystallised at pressures of 0.25 and 0.6 GPa and subsequently recovered to ambient pressure. The structures are the first reported examples of ciprofloxacin chelating a Group IA monovalent cation. Ambient-pressure crystallisation of the same solution used for high-pressure experiments, yielded crystals of the known hexahydrate. In a parallel study, the previously unknown structure of anhydrous ciprofloxacin was determined from powder diffraction data. The structures are described and compared using the XPac method.

Graphical abstract: Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure

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Article information

DOI
https://doi.org/10.1039/B822987B
Article type
Paper
Submitted
22 Dec 2008
Accepted
02 Mar 2009
First published
25 Mar 2009

CrystEngComm, 2009,11, 1396-1406

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Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure

F. P. A. Fabbiani, B. Dittrich, A. J. Florence, T. Gelbrich, M. B. Hursthouse, W. F. Kuhs, N. Shankland and H. Sowa, CrystEngComm, 2009, 11, 1396 DOI: 10.1039/B822987B

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