Issue 5, 2006
From the journal:

Journal of Materials Chemistry

Functionalization of mesoporous materials with long alkyl chains as a strategy for controlling drug delivery pattern

Juan C. Doadrio,a   Edesia M. B. Sousa,a   Isabel Izquierdo-Barba,a   Antonio L. Doadrio,a   Joaquin Perez-Parientea  and  María Vallet-Regí*a  

* Corresponding authors

a Departamento de Química Inorgánica y Bioinorgánica. Facultad de Farmacia. Universidad Complutense, Pza. Ramón y Cajal s/n Madrid., Spain
E-mail: vallet@farm.ucm.es
Fax: +34-913941786
Tel: +34-913941861

Abstract

Mesoporous silica SBA-15 was prepared to evaluate its effectiveness as a matrix for the controlled delivery of macrolide-type antibiotics. Two types of material were used to evaluate the delivery: calcined samples and samples functionalized with octyltrimethoxysilane and octadecyltrimethoxysilane. The samples were charged with the macrolide antibiotic erythromycin and the release assays were carried out in vitro. It has been observed that the release rate decreases as the population of hydrophobic –CH2 moieties in the host increases.

Graphical abstract: Functionalization of mesoporous materials with long alkyl chains as a strategy for controlling drug delivery pattern

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Article information

DOI
https://doi.org/10.1039/B510101H
Article type
Paper
Submitted
05 Jul 2005
Accepted
31 Oct 2005
First published
18 Nov 2005

J. Mater. Chem., 2006,16, 462-466

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Functionalization of mesoporous materials with long alkyl chains as a strategy for controlling drug delivery pattern

J. C. Doadrio, E. M. B. Sousa, I. Izquierdo-Barba, A. L. Doadrio, J. Perez-Pariente and M. Vallet-Regí, J. Mater. Chem., 2006, 16, 462 DOI: 10.1039/B510101H

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