Issue 12, 2004
From the journal:

Chemical Communications

Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

Nial J. Wheate,ab   Anthony I. Day,b   Rodney J. Blanch,b   Alan P. Arnold,b   Carleen Cullinanec  and  J. Grant Collins*b  

* Corresponding authors

a Joint Health Support Agency, Department of Defence, Campbell Park Offices, Campbell, ACT, 2600, Australia
E-mail: nial.wheate@defence.gov.au
Fax: +61 02 6266 2134
Tel: +61 02 6266 3822

b School of Physical, Environmental and Mathematical Sciences, University College, University of New South Wales, Australian Defence Force Academy, Northcott Drive, Campbell, ACT, 2600, Australia
E-mail: g.collins@adfa.edu.au
Fax: +61 02 6268 8002
Tel: +61 02 6268 8077

c Pharmacology and Developmental Therapeutics Unit, Peter MacCallum Cancer Centre, Locked Bag No. 1, A'Beckett Street, Melbourne, Victoria, 8006, Australia
E-mail: c.cullinane@petermac.org
Fax: + 61 03 9656 1411
Tel: +61 03 9656 1275

Abstract

The dinuclear platinum complex trans-[{Pt(NH3)2Cl}2μ-dpzm]2+ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.

Graphical abstract: Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B404358H
Article type
Communication
Submitted
23 Mar 2004
Accepted
28 Apr 2004
First published
18 May 2004

Chem. Commun., 2004, 1424-1425

Permissions

Request permissions

Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

N. J. Wheate, A. I. Day, R. J. Blanch, A. P. Arnold, C. Cullinane and J. Grant Collins, Chem. Commun., 2004, 1424 DOI: 10.1039/B404358H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements