Dihydropyran-2-carboxylic acid, a novel bifunctional linker for the solid-phase synthesis of peptides containing a C-terminal alcohol

Abstract

Dihydropyran-2-carboxylic acid, a novel compound used to link an amino alcohol and an amine resin, is utilised for the solid-phase synthesis of peptide alcohols via the Fmoc strategy; this bifunctional linker was effectively applied to the synthesis of Octreotide.

References

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