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DOI: 10.1039/A700654C (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1997, 2111-2122

Haem d1: development of a new coupling procedure leading to the synthesis of isobacteriochlorins[hair space]1

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Richard L. Mackman, Jason Micklefield, Michael H. Block, Finian J. Leeper and Alan R. Battersby

Abstract

A new approach has been developed for construction of the western and eastern lactams, e.g. 2 and 3, needed for synthesis of isobacteriochlorins. It involves acylation of pyrroles with lactonic acids to form ketones. These are then efficiently converted into the desired lactams by a short sequence of reactions. All the steps are high yielding and simple to carry out.

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