Novel site-specific one-step bromination of substituted benzenes

Abstract

Regiospecific bromination of benzene derivatives has been carried out with Me₂SO–HBr; this method gives excellent yields of 2-bromobenzaldehyde and 2-bromonitrobenzene; strong ortho- and para-directing monosubstituted benzenes give para-bromo derivatives; a general discussion of the mechanism of these reactions is given.