α-Keto a ids are readily decarboxylated via imine formation with primary and/or secondary amines even when imine–enamine isomerisation can occur; the process is thoyghy to involve an intermediate zwitteriion which can be trapped by sulphur to give thiamides in excellent yield.
M. F. Aly and R. Grigg, J. Chem. Soc., Chem. Commun., 1985, 1523 DOI: 10.1039/C39850001523
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