A general method for the enantio-efficient synthesis of β-aminoalanine derivatives, which involves intramolecular transfer of the amino substituent from the αcarboxy to the β-carbon atom via an azetidinone is described with its application to an efficient synthesis of the neuroexcitatory quisqualic acid in an optically pure state.
J. E. Baldwin, R. M. Adlington and D. J. Birch, J. Chem. Soc., Chem. Commun., 1985, 256 DOI: 10.1039/C39850000256
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