Functionalization of pyridine via direct metallation
Abstract
The isolation of mixtures of 2-, 3-, and 4-deuteriopyridine, 2-, 3-, and 4-trimethylsilylpyridine, or 2-, 3-, and 4-methylthiopyridine indicates successful metallation of pyridine with a 1 : 1 mixture of BuLi-ButOK in tetrahydrofuran–hexane at ––100 °C.