Formation of aziridinones (α-lactams) from hydroxamic derivatives
Abstract
Various NO-disubstituted derivatives of chloroaceto- and phenylaceto-hydroxamic acid are shown to cyclise with base to give aziridinones with cleavage of the N–O bond, a process exemplified by an efficient synthesis of 1-t-buty-3-phenylaziridin-2-one.
 
                



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