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Chemical Science

For findings of exceptional significance from across the chemical sciences
All articles free to read, free to publish* from 2015
*Article processing charges waived for articles published in 2015 and 2016
Impact Factor 8.601 12 Issues per Year Immediacy Index 3.07
 
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William Hart-Cooper, Chen Zhao, Rebecc Triano, Parastou Yaghoubi, Haxel Lionel Ozores, Kristen Burford, F Dean Toste, Robert G Bergman and Kenneth Raymond
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC02735C, Edge Article
The effect of host structure on the selectivity and mechanism of intramolecular Prins reactions is evaluated using K12Ga4L6 tetrahedral catalysts. The host structure was varied by modifying the structure of...
 
Miquel A Pericas, Lourdes Maestre, Erhan Ozkal, Carles Ayats, Alvaro Beltran, M Mar Diaz-Requejo and Pedro J. Perez
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC03277B, Edge Article
A polystyrene-linked tris(triazolyl)methanecopper(I) cationic catalyst operates under heterogeneous conditions for the reaction of ethyl diazoacetate (EDA) with an array of substrates. Carbon-hydrogen as well as X-H (X = O, N)...
 
Valentín Hornillos, Massimo Giannerini, Carlos Vila, Martín Fañanás-Mastral and Ben L Feringa
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC03117B, Edge Article
A catalytic method for the direct cross-coupling of alkenyllithium reagents with aryl- and alkenyl halides is described. The use of a catalyst comprising Pd2(dba)3/XPhos allows for the stereoselective preparation of...
 
N S Simpkins, Louise Male, Alejandro Cabanillas and Christopher Davies
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC03218G, Edge Article
Michael addition reactions of triketopiperazine (TKP) derivatives to enones, mediated by a cinchona alkaloid-derived catalyst, deliver products in high yield and enantiomeric ratio (er). Use of unsaturated ester, nitrile or...
 
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC03074E, Edge Article
Palladium-catalyzed 1,4-difunctionalizations of isoprene that produce skipped polyenes are reported. Complex isomeric product mixtures are possible as a result of the difficult-to-control migratory insertion of isoprene into a Pd-alkenyl bond,...
 
Manfred Scheer, Christian Grassl, Michael Bodensteiner and Manfred Zabel
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC03543G, Edge Article
The reaction of [{η5-Cp‘‘‘Co}2{µ,η4:4-toluene}] with yellow arsenic yields the arsenic-rich Asn ligand complexes [{Cp‘‘‘Co(µ,η2:2-As2)}2] (1), [(Cp‘‘‘Co)4(µ4,η4:4:2:2:1:1-As10)] (2) and [(Cp‘‘‘Co)3(µ3,η4:4:2:1-As12)] (3), which were comprehensively characterized. The molecular structure of 1 show...
 
Taku Hasobe, Toru Aoki, Hayato Sakai, Kei Ohkubo, Tomo Sakanoue, Taishi Takenobu and Shunichi Fukuzumi
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC02787F, Edge Article
Charge-transfer (CT) π-complexes are formed between planar porphyrins and 1,4,5,8,9,12-hexaazatriphenylene (HAT) derivatives with large formation constants (e.g., 104 M–1), exhibiting broad CT absorption bands. The unusually large formation constants result...
 
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC02714K, Edge Article
A hybrid catalyst in which two different types of enzyme mimics are positioned in spatially separate domains within a graphene–mesoporous silica support is presented.
 
Süleyman Er, Changwon Suh, Michael P. Marshak and Alán Aspuru-Guzik
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC03030C, Edge Article
We demonstrate a successful high-throughput screening approach for the discovery of inexpensive, redox-active quinone molecules for organic-based aqueous flow batteries.
 
Lena Hesping, Anup Biswas, Constantin G. Daniliuc, Christian Mück-Lichtenfeld and Armido Studer
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC02612H, Edge Article
Pyrazolidinones with a tetrahydroisoquinoline core are obtained with excellent diastereocontrol and high enantioselectivity. Theoretical studies give insight on the reaction mechanism.
 
Victor Sans, Luzian Porwol, Vincenza Dragone and Leroy Cronin
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC03075C, Edge Article
A ‘dial-a-molecule’ platform for algorithm driven organic synthesis using real-time feedback, via in-line flow NMR spectroscopy, is demonstrated.
 
L. Chan, A. McNally, Q. Y. Toh, A. Mendoza and M. J. Gaunt
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC02856B, Edge Article
A mild and transition metal-free counteranion triggered arylation strategy has been developed using diaryliodonium fluorides.
 
Ai-Hua Zhou, Qiao He, Chao Shu, Yong-Fei Yu, Shuang Liu, Tian Zhao, Wei Zhang, Xin Lu and Long-Wu Ye
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC02596B, Edge Article
An unprecedented gold-catalyzed formal [3+2] cycloaddition between ynamides and isoxazoles has been developed, allowing rapid and practical access to a wide range of synthetically useful 2-aminopyrroles.
 
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC03342F, Edge Article
ABSTRACT: Efficient photoredox catalysts containing transition metals, such as iridium and ruthenium, to initiate organic reactions and polymerization under visible light have recently emerged. However, these catalysts are composed of...
 
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC02676D, Edge Article
We report the first photoinduced single-crystal-to-single-crystal (SCSC) phase transition of a gold complex that involves shortening of intermolecular aurophilic bonds. This is also the first solid state photochromism of a...
 
Elizabeth A. Proctor, Pradeep Kota, Andrei A. Aleksandrov, Lihua He, John R. Riordan and Nikolay V. Dokholyan
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC01320D, Edge Article
A novel approach identifying networks of residues involved in trans-protein dynamic coupling is applied to rescue mutant CFTR.
 
Yasmina Mekmouche, Ludovic Schneider, Pierre Rousselot-Pailley, Bruno Faure, A. Jalila Simaan, Constance Bochot, Marius Réglier and Thierry Tron
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC02564D, Edge Article
Combining a palladium-based complex with a laccase allows the oxidation of an alcohol substrate at room temperature and atmospheric pressure.
 
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC03200D, Edge Article
Ultraviolet photodissociation (UVPD) mass spectrometry is employed to investigate the structure of holo-myoglobin as well as its apo form transferred to the gas phase by native electrospray. UVPD provided insight...
 
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC03182B, Edge Article
Chemo-enzymatic strategies provide a highly selective means to label different classes of biomolecules in vitro, but also in vivo. In the field of RNA, efficient labeling of eukaryotic mRNA with...
 
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC02340D, Edge Article
Studying protein ubiquitination is difficult due to the complexity of the E1-E2-E3 ubiquitination cascade. Here we report the discovery that C-terminal ubiquitin thioesters can undergo direct transthiolation with the catalytic...
 
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC02806F, Edge Article
The restructuring of nanoparticles at the in situ condition is a common but complex phenomenon in nanoscience. Here, we present a first systematic survey on the structure dynamics and its...
 
Ahmed Zubi, Ashley Wragg, Harry Adams, Simon Turega, Paulo J. Costa, Vitor Felix and Jim Thomas
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC02799J, Edge Article
Metal directed self-assembly has become a much-studied route towards complex molecular architectures. Although studies on mixed valence, MV, systems accessible through this approach are almost non-existent, the potential applications of...
 
C. Adrian Figg, Alexandre Simula, Kalkidan A. Gebre, Bryan S. Tucker, David M. Haddleton and Brent S. Sumerlin
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC03334E, Edge Article
Polymerization-induced thermal self-assembly (PITSA) was conducted using thermoresponsive poly(N-isopropylacrylamide) to result in micelle, worm, and vesicle polymeric morphologies.
 
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC02610A, Edge Article
Co(II)-based metalloradical catalysis has, for the first time, been successfully applied for asymmetric intramolecular C–H alkylation of acceptor/acceptor-substituted diazo reagents.
 
Ji Nie, Ming-Zhe Zhao, Wen Jun Xie, Liang-Yuan Cai, Ying-Lin Zhou and Xin-Xiang Zhang
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC03225J, Edge Article
A novel DNA cross-triggered cascading self-amplification artificial biochemical circuit can be triggered by either of two fully independent oligonucleotide factors ([similar]2 amol) and amplify both of them by 105–107 fold.
 

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