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Chemical Science

For findings of exceptional significance from across the chemical sciences
All articles free to read, free to publish* from 2015
*Open Access with no publication charges until end of 2018
Impact Factor 9.211 12 Issues per Year
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Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC00932H, Edge Article
We present an efficient and unified strategy for the enantioselective syntheses of various iboga alkaloids and vinblastine, involving gold-catalyzed oxidation and Stevens rearrangement. New vinblastine analogs were prepared by our 10-step synthesis.
Jonathan L. Marshall, Kazuyuki Uchida, Conerd K. Frederickson, Christian Schütt, Andrew M. Zeidell, Katelyn P. Goetz, Tristan W. Finn, Karol Jarolimek, Lev N. Zakharov, Chad Risko, Rainer Herges, Oana D. Jurchescu and Michael M. Haley
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC00950F, Edge Article
Exchanging fused benzenes for benzothiophenes results in pronounced antiaromaticity in the indacene core.
Ye Bi, Cheng Chen, Yi-Fang Zhao, Yi-Quan Zhang, Shang-Da Jiang, Bing-Wu Wang, Jun-Bo Han, Jun-Liang Sun, Zu-Qiang Bian, Zhe-Ming Wang and Song Gao
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC01157H, Edge Article
A series of promising multifunctional lanthanide single-molecule magnets (SMMs). Lanthanide luminescence under a pulsed magnetic field for SMMs is examined for the first time.
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC00481D, Edge Article
We report cancer cell selective activation of mitochondrial ATP synthase using a suitably designed chemical formulation of alpha-tocopheryl succinate.
Manuela A. Gross, Charles E. Creissen, Katherine L. Orchard and Erwin Reisner
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC00715E, Edge Article
Layer-by-layer assembly of a Ru dye and Ni catalyst on a p-type NiO photocathode enables photoelectrochemical H2 generation in water.
Nishant Singh, Kai Zhang, César A. Angulo-Pachón, Eduardo Mendes, Jan H. van Esch and Beatriu Escuder
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC01268J, Edge Article
We report the orthogonal assembly of two structurally dissimilar catalytic hydrogelators with mutually incompatible functional groups able to retain their individual catalytic activity and thus catalyse tandem reactions in one pot.
Albano Galán, Gemma Aragay and Pablo Ballester
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC01843B, Edge Article
We describe our results in the attempted template syntheses of oligomacrocycle calix[4]pyrrole dimer 4, using Hay coupling reaction conditions, tetraalkynyl calix[4]pyrrole 5 as starting material and two bipyridyl N-oxides of...
Jingye Zhang, Zining Liu, Peng Lian, Jun Qian, Xinwei Li, Lu Wang, Wei Fu, Liang Chen, Xunbin Wei and Cong Li
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC00221H, Edge Article
Accurately locating and eradicating sporadically distributed cancer cells whilst minimizing damage to adjacent normal tissues is vital in image-guided tumor ablation. In this work, we developed four heptamethine cyanine based...
Vincent Lebrun, Jean-Luc Ravanat, Jean-Marc Latour and Olivier Sénèque
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC00974C, Edge Article
Reaction rate constants of HOCl with zinc-bound cysteines are determined, demonstrating that zinc fingers are potent targets for HOCl and may serve as HOCl sensors.
Sungmin Park, Jin Hyuck Heo, Jae Hoon Yun, Tae Sub Jung, Kyungwon Kwak, Min Jae Ko, Cheol Hong Cheon, Jin Young Kim, Sang Hyuk Im and Hae Jung Son
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC00876C, Edge Article
The performance of planar perovskite solar cells was enhanced by using hole transporting materials containing triphenylamine groups with a multi-armed structure.
Hwan Bae, Jun Young Jang, Sun-Sil Choi, Jae-Jin Lee, Heejun Kim, Ala Jo, Kong-Joo Lee, Jang Hyun Choi, Se Won Suh and Seung Bum Park
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC01279E, Edge Article
We revealed the X-ray structure of PPARγ co-crystallized with SR1664 bound to the alternate binding site of PPARγ and confirmed that this blocks the phosphorylation of Ser273.
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC01195K, Edge Article
We demonstrate the successful use of Eu3+-activated core–shell–shell nanoprobes for in vitro upconverting/downshifting luminescent detection of a cancer biomarker of alpha-fetoprotein.
Fereidoon Daryaee, Andrew Chang, Johannes Schiebel, Yang Lu, Zhuo Zhang, Kanishk Kapilashrami, Stephen G Walker, Caroline Kisker, Christoph Sotriffer, Stewart L Fisher and P. Tonge
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC01000H, Edge Article
Drug-target kinetics enable time-dependent changes in target engagement to be quantified as a function of drug concentration. When coupled to drug pharmacokinetics (PK), drug-target kinetics can thus be used to...
Chizhong Wang, Takashi Hisatomi, Tsutomu Minegishi, Mamiko Nakabayashi, Naoya Shibata, Masao Katayama and Kazunari Domen
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC01763K, Edge Article
The fabrication of semiconductor films on conductive substrates is vital to the production of high-performance electrodes for photoelectrochemical (PEC) water splitting. In this work, a thin film transfer method was...
Hong Wang, Xinggui Gu, Rongrong Hu, Jacky Wing Yip Lam, Deqing Zhang and Ben Zhong Tang
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC01703G, Edge Article
The marriage of reflected light originated from photonic crystal (PC) and emitted light would create miraculous phenomena. However, the traditional luminophores cannot avoid the problem of aggregation-caused quenching. To solve...
Hui Xue, Qihui Chen, Daqiang Yuan, GuangXun Lyu, Linfeng Liang, Luyao Liu and Maochun Hong
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC00972G, Edge Article
An extraordinary metal-organic framework FJI-H9 for reversible uptake of Cd(II) with high adsorption and selectivity has been developed. Further research indicates that such high absorption results from an unusual synergy...
Avinash Patil, Stephen Mann, Ravinash Krishnakumar and Robert L Harniman
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC00205F, Edge Article
A functionalized small-molecule dipeptide capable of structural adaptation is used to prepare coacervate-based protocells that exhibit a pH-triggered process of self-transformation and structural reconfiguration. Polymer-dipeptide coacervate micro-droplets are prepared at...
Yi Shen, Adam Roberge, Rui Tan, Megan Y Gee, Dylan Gary, Yucheng Huang, Douglas A Blom, Brian Benicewicz, Brandi Cossairt and Andrew Greytak
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC01301E, Edge Article
This article illustrates the use of gel permeation chromatography (GPC, organic-phase size exclusion chromatography) to separate nanocrystals from weakly-bound small molecules, including solvent, on the basis of size. A variety...
Wei Liu, Charles Truillet, Robert R. Flavell, Thomas F. Brewer, Michael J. Evans, David M. Wilson and Christopher J. Chang
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC01503D, Edge Article
We present an aza-Cope-based reactivity probe for imaging formaldehyde in vivo using positron emission tomography.
Zhao Hu, Weifei Fu, Lijia Yan, Jingsheng Miao, Hongtao Yu, Yaowu He, Osamu Goto, Hong Meng, Hongzheng Chen and Wei Huang
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC00973E, Edge Article
By introducing the heteroatom into the benchmark hole transport material Spiro-MeOTAD, the energy level of hole transport materials can be tuned.
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC01075J, Edge Article
Efficient diastereoselective rhodium catalyzed synthesis of indolines possessing two contiguous tetrasubstituted carbon centers have been achieved in good to excellent yield from ortho-vinylanilines and iminocarbenes derived from N-sulfonyl-1,2,3-triazoles. The reaction...
Xiaofan Ji, Hu Wang, Yang Li, Danyu Xia, Hao Li, GP Tang, Jonathan L Sessler and Feihe Huang
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC01851C, Edge Article
We report here a new approach to creating diversiform copolymer-derived self-assembly morphologies that relies on macrocycle/anion recognition in aqueous media. This approach exploits the anion binding features of a water-soluble...
Peng Gao, Sanghyun Paek, Iwan Zimmermann, Paul Gratia, Kasparas Rakstys, G. Grancini, Nazeeruddin, Mohammad K., A. R. Malik, Malik Abdul Rub, Samia A. Kousa and Khalid A. Alamry
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC01478J, Edge Article
Donor-π-Bridge-Donor type oligomers (D-π-D) have been studied intensively as active materials for organic optoelectronic devices. In this study, we introduce three new D-π-D type organic semiconductors incorporating thiophene or thienothiophene...
Nazario Martin, Sara H. Mejias, Javier López-Andarias, Tsuneaki Sakurai, Satoru Yoneda, Kevin P. Erazo, Shu Seki, Carmen Atienza and Aitziber L Cortajarena
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC01306F, Edge Article
The precise control over the organization of photoactive components at the nanoscale is one of the main challenges for the generation of new and sophisticated macroscopically ordered materials with enhanced...
Ivo Stassen, Bart Bueken, Helge Reinsch, Jos Oudenhoven, Daan Wouters, Julianna Hajek, Veronique Van Speybroeck, Norbert Stock, Philippe M Vereecken, Rob Van Schaijk, Dirk E. De Vos and Rob Ameloot
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC00987E, Edge Article
We present a highly sensitive gas detection approach for the infamous 'nerve agent' group of alkyl phosphonate compounds. Signal transduction is achieved by monitoring of the work function shift of...

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