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Journal cover: Chemical Science

Chemical Science

For findings of exceptional significance from across the chemical sciences
All articles free to read, free to publish* from 2015
*Open Access and publication charge waiver extended
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Thorfinnur Gunnlaugsson, Sankarasekaran Shanmugaraju, Charlyne Dabadie, Kevin Byrne, A J. Savyasachi, Deivasigamani Umadevi, Wolfgang Schmitt and Jonathan A Kitchen
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC04367D, Edge Article
V-shaped 4-amino-1,8-napthalimide derived tetracarboxylic acid linker (L; bis-[N-(1,3-benzenedicarboxylic acid)]-9,18-methano-1,8-naphthalmide-[b,f][1,5]diazocine) comprising the Tröger’s base (TB) structural motif was rationally designed and synthesised to access a nitrogen-rich fluorescent supramolecular coordination polymer. By...
Arghya Sadhukhan, Melanie Hobbs, Anthony J. H. M. Meijer and Iain Coldham
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC03712G, Edge Article
We report the deprotonation of a chiral nitrile and reaction of the resulting chiral organometallic species with a variety of electrophiles to give highly enantiomerically enriched 2-substituted nitrile products. The...
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC04273B, Edge Article
Chiral alpha,beta-unsaturated acylammonium salts are novel dienophiles enabling enantioselective Diels-Alder-lactonization (DAL) organocascades leading to cis- and trans-fused, bicyclic gamma- and delta-lactones from readily prepared dienes, commodity acid chlorides, and a...
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC02333A, Edge Article
A general gas diffusion strategy using 10,12-pentacosadiynoic acid as a ligand and ethanol as a solvent was developed to fabricate stable amorphous mineral clusters with a core size of less than 2 nm.
Jeong Chan Joo, Anna N. Khusnutdinova, Robert Flick, Taeho Kim, Uwe T. Bornscheuer, Alexander F. Yakunin and Radhakrishnan Mahadevan
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC02842J, Edge Article
We demonstrate the first enzymatic hydrogenation of 2-hexenedioic acid and muconic acid to adipic acid using enoate reductases (ERs).
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC03702J, Edge Article
The immune system is an essential component of host defense against pathogens and is largely mediated by inflammatory molecules produced by immune cells, such as macrophages. These inflammatory mediators are...
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC03879D, Edge Article
Fluorogenic probes for bioorthogonal labeling chemistry are highly beneficial to reduce background signal in fluorescence microscopy imaging. 1,2,4,5-Tetrazines are known substrates for the bioorthogonal inverse electron demand Diels-Alder reaction (DAinv)...
Marta Artola, Laura B. Ruíz-Ávila, Erney Ramirez-Aportela, R. Fernando Martínez, Lidia Araujo-Bazán, Henar Vazquez-Villa, Mar Martín-Fontecha, María A. Oliva, A. Javier Martín-Galiano, Pablo Chacón, María L. López-Rodríguez, Jose Manuel Andreu and Sonia Huecas
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC03792E, Edge Article
FtsZ is a widely conserved tubulin-like GTPase that directs bacterial cell division and a new target for antibiotic discovery. This protein assembly machine cooperatively polymerizes forming single-stranded filaments, by means...
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC04381J, Edge Article
We report a strategy for efficient post-translational modification of a library of ribosomally-translated peptides by activation and elimination of cysteine to dehydroalanine then conjugate addition of a range of exogenous...
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC03745C, Edge Article
Byproducts of chemical reactions are generally thought to result from the competition between two reaction pathways, each with its own rate-determining transition state structure. We show here, however, that pathways...
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC03722D, Edge Article
Formation of the small, highly charged tetraanion ferrocyanide, Fe(CN)64−, stabilized in aqueous nanodrops and its influence to the surrounding hydrogen-bonding network of water is reported.
Tessa M. Baker, Toshiki G. Nakashige, Elizabeth M. Nolan and Michael L. Neidig
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC03487J, Edge Article
Magnetic circular dichroism studies of Fe(II) binding to human calprotectin demonstrate the nature of Fe(II) coordination at two different Fe(II)-binding sites and provide insight into how Ca(II) modulates Fe(II) coordination.
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC03642B, Edge Article
It has been well established that long range secondary electrostatic interactions (SEIs) have a significant effect on the stability of supramolecular complexes.
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC03003C, Edge Article
Post-translational modifications (PTMs) on histone tails act in diverse combinations in the ‘histone code’ to control gene expression, with dysregulation observed in a variety of diseases. However, detection and sensing...
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC03207A, Edge Article
An unprecedented family of novel electron-donor acceptor conjugates based on fullerenes have been synthesized and characterized in a variety of solvents.
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC04083G, Edge Article
Undetectable NMR signals of host–guest assemblies can be amplified by two orders of magnitude using the proposed GEST methodology.
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC03849B, Edge Article
A chiral heterogeneous material was prepared and evaluated as a bifunctional catalyst for the sequential aerobic oxidation-asymmetric intramolecular aza-Friedel–Crafts reaction.
Brandon E. Haines, Takahiro Kawakami, Keiko Kuwata, Kei Murakami, Kenichiro Itami and D G Musaev
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC04145K, Edge Article
The LCuBr-catalyzed C–H imidation of arenes by N-fluorobenzenesulfonimide (NFSI), previously reported by us, utilizes an inexpensive catalyst and is applicable to a broad scope of complex arenes. The computational and...
Katharina Märker, Subhradip Paul, Carlos Fernandez-de-Alba, Daniel Lee, Jean-Marie Mouesca, Sabine Hediger and Gaël De Paëpe
Chem. Sci., 2016, Accepted Manuscript
DOI: 10.1039/C6SC02709A, Edge Article
The self-assembly of small organic molecules is an intriguing phenomenon, which provides nanoscale structures for applications in numerous fields from medicine to molecular electronics. Detailed knowledge of their structure, in...
Biswarup Jash, Philipp Scharf, Nikolas Sandmann, Célia Fonseca Guerra, Dominik A. Megger and Jens Müller
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC03482A, Edge Article
A molecular beacon has been developed that depends on the formation of a metal-mediated base pair.
Alexander S. Groombridge, Aniello Palma, Richard M. Parker, Chris Abell and Oren A. Scherman
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC04103E, Edge Article
The successful self-assembly of a stimuli-responsive aqueous supramolecular hyperbranched polymer from small molecules and the macrocyclic host cucurbit[8]uril (CB[8]) is reported. This self-healing supramolecular network can act as a soft matter barrier at liquid–liquid interfaces.
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC04006C, Edge Article
High enantioselectivities can be achieved using an appropriate chiral base/achiral ligand combination in Pd0-catalyzed C(sp3)–H activation.
Iago Pereiro, Amel Bendali, Sanae Tabnaoui, Lucile Alexandre, Jana Srbova, Zuzana Bilkova, Shane Deegan, Lokesh Joshi, Jean-Louis Viovy, Laurent Malaquin, Bruno Dupuy and Stéphanie Descroix
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC03880H, Edge Article
A microfluidic fluidized bed composed of antibody-grafted magnetic beads for the fast visual detection of bacteria by in situ expansion phenomena.
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC02928K, Edge Article
Direct attachment of a photoactive bis-thienyl unit to benzo[b]phosphole oxide has led to a new photochromic compound that shows excellent performance in ambient thin film conditions.
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC02390H, Edge Article
Zwitterionic group 14 complexes of the alkali metals of formula [E(SiMe2OCH2CH2OMe)3M], where E = C, Si or Ge and M = Li, Na or K, have been prepared, structurally characterized and their electronic nature was investigated by computational methods.

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138 citations
A reversible photo-induced instability has been found in mixed-halide photovoltaic perovskites that limits the open circuit voltage in solar cells.
DOI: 10.1039/C4SC03141E
Published: 04 Nov 2014
63 citations
The combination of quantum yield and luminescence quenching measurements provides a method to rapidly characterize the occurrence of chain processes in a variety of photoredox reactions.
DOI: 10.1039/C5SC02185E
Published: 07 Jul 2015
32 citations
Direct splitting of pure water into H2 and O2 in a stoichiometric molar ratio of 2 : 1 by conjugated polymers via a 4-electron pathway was established for the first time, as demonstrated here using a g-C3N4 polymer and redox co-catalysts of Pt and Co species.
DOI: 10.1039/C5SC04572J
Published: 27 Jan 2016

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