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Chemical Science

For findings of exceptional significance from across the chemical sciences
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Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC04647A, Edge Article
Signaling by G-protein coupled receptors usually occurs via ternary complexes formed under cooperative binding between the receptor, a ligand and an intracellular binding partner (a G-protein or β-arrestin). We have...
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00789B, Edge Article
An antibacterial cyclic AS-48 protein was chemically synthesized by α-ketoacid hydroxylamine (KAHA) ligation. Initial challenges with the exceptionally hydrophobic segments arising from the amphiphilic nature of the protein were solved...
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00586E, Edge Article
Vibrational structure in the near-UV circular dichroism (CD) spectra of proteins is an important source of information on protein conformation and can be exploited to study structure and folding. A...
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05697K, Edge Article
An important challenge in Cα-heteroarylation of ethers is the requirement of a large excess amount (used as solvents in many cases) of ethers to achieve effective transformations. This drawback has...
Hui Wang, Shenlong Jiang, Shichuan Chen, Xiaodong Zhang, Wei Shao, Xianshun Sun, Zhi Zhao, Qun Zhang, yi luo and Yi Xie
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00307B, Edge Article
Understanding the photoexcitation processes in semiconductors is critical for the design of advanced photocatalytic materials. Nevertheless, traditional viewpoints focus on the photogenerated free charge carriers, which are somehow invalid once...
Anthony Jose Rojas, Chi Zhang, Ekaterina V. Vinogradova, Nathan Buchwald, John Reilly, Bradley Pentelute and Stephen Buchwald
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05454D, Edge Article
Macrocyclic peptides are important therapeutic candidates due to their improved physicochemical properties in comparison to their linear counterparts. Here we detail a method for a divergent macrocyclisation of unprotected peptides...
Hung-Wing Li, Man Shing Wong, Di Xu, See-Lok Ho and Hei-Nga Chan
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05615F, Edge Article
Beta Amyloid peptide, tau and phosphorylated tau are well recognized as the promising biomarkers in diagnosis of Alzheimer’s disease (AD). In this work, we developed a direct, versatile and ultrasensitive...
Aydin Ozcan, Claudio Perego, Matteo Salvalaglio, Michele Parrinello and Ozgur Yazaydin
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC04978H, Edge Article
We introduce a new non-equilibrium molecular dynamics method which creates a continuous and steady-state concentration gradient along a membrane.
Daniel Muñoz-Santiburcio and Dominik Marx
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC04989C, Edge Article
Nanoconfined liquids have extremely different properties from the bulk, which profoundly affects chemical reactions taking place in nanosolvation.
Fereidoon Daryaee, Zhuo Zhang, Kayla R. Gogarty, Yong Li, Jonathan Merino, Stewart L. Fisher and Peter J. Tonge
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC03306G, Edge Article
Correlating target engagement with in vivo drug activity remains a central challenge in efforts to improve the efficiency of drug discovery.
Zhong-Fu Pang, Tian-You Zhou, Rong-Ran Liang, Qiao-Yan Qi and Xin Zhao
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC05673C, Edge Article
Regulating the topology of 2D COFs has been achieved by introducing alkyl substituents into the skeleton of a parent monomer, which led to the formation of a dual-pore COF or single-pore COFs, depending on the sizes of the substituents.
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC04235J, Edge Article
Combinatorial biosynthesis for more efficient antibiotics: 150 novel lincosamides prepared by combining lincomycin and celesticetin biosynthetic pathways.
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00161D, Edge Article
A concise total synthesis of aristolactam alkaloids in a synergistic combination of reactions of C H bond activation and dehydro-Diels-Alder is described. To success the synthesis, two new synthetic methodologies...
Bart Bueken, Niels Van Velthoven, Tom Willhammar, Timothée Stassin, Ivo Stassen, David A. Keen, Gino V. Baron, Joeri F M Denayer, Rob Ameloot, Sara Bals, Dirk E. De Vos and thomas Douglas bennett
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05602D, Edge Article
The ability of metal-organic frameworks (MOFs) to gelate under specific synthetic conditions opens up new opportunities in the preparation and shaping of hierarchically porous MOF monoliths, which could be directly...
Wasinee Phonsri, Phimphaka Harding, Lujia Liu, Shane Telfer, Keith S. Murray, Boujemaa Moubaraki, Tamsyn M. Ross, Guy N L Jameson and David J. Harding
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05317C, Edge Article
Solvent effects in a series of Fe(III) spin crossover (SCO) complexes [Fe(qsal-I)2]OTf·sol (sol = MeOH 1, EtOH 2, n-PrOH 3, i-PrOH 4, acetone 5 and MeCN 6) are explored. SCO...
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00367F, Edge Article
Palladium-catalyzed denitrogenative Suzuki and carbonylative Suzuki reactions of benzotriazoles with boronic acids have been achieved through the in situ generation of ortho-amino-arenediazonium species.
Toyokazu Tanabe, Tsubasa Imai, Tomoharu Tokunaga, Shigeo Arai, Yuta Yamamoto, Shigenori Ueda, Gubbala V. Ramesh, Satoshi Nagao, Hirohito Hirata, Shin-ichi Matsumoto, Takeshi Fujita and Hideki Abe
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC05473K, Edge Article
Nanophase-separated Ni3Nb alloy exhibited higher performance than traditional Pt catalysts toward the remediation of automobile exhaust.
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00549K, Edge Article
A novel computational method based on a procedure combining accelerated direct dynamics with an efficient geometry-based post-processing algorithm is proposed for use in discovering reaction mechanisms and solving the kinetics of transition metal-catalyzed reactions.
Shunying Liu, Jun Jiang, Jianghui Chen, Qinghua Wei, Wenfeng Yao, Fei Xia and Wenhao Hu
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00257B, Edge Article
Metal-associated carbenes from diazo compounds promote many useful chemistry transformations in modern organic chemistry. However, compared to α-aryldiazoacetate-derived carbenes (ArDC), the synthetic application of α- alkyldiazoacetates-derived carbenes (AlDC) is greatly...
Yang Liu, Lizeth Perez, Magi Mettry, Adam D. Gill, Samantha R Byers, Connor J Easley, Christopher J. Bardeen, Wenwan Zhong and Richard James Hooley
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00865A, Edge Article
Variably functionalized self-folding deep cavitands form an arrayed, fluorescent indicator displacement assay system for the detection of post-translationally modified (PTM) histone peptides. The hosts bind trimethyllysine (KMe3) groups, and use...
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00318H, Edge Article
Mechanistic control is a powerful mean for manufacturing specific shape of metal nanostructures and optimizing their performance in a verity of applications. Thus, we successfully synthesized multimetallic nanoplates (PtAgBiCo and...
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00250E, Edge Article
Copper-catalyzed C(sp3)–H/C(sp2)–H cross-coupling via directed 1,5-hydrogen atom transfer has been developed to construct 6-membered carbocyclic rings.
Brigitte Renoux, Florian Raes, Thibaut Legigan, Elodie Péraudeau, Balkis Eddhif, Pauline Poinot, Isabelle Tranoy-Opalinski, Jérôme Alsarraf, Oleksandr Koniev, Sergii Kolodych, Stéphanie Lerondel, Alain Le Pape, Jonathan Clarhaut and Sébastien Papot
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00472A, Edge Article
A drug delivery system targeting the tumour microenvironment produces outstanding therapeutic efficacy on triple-negative mammary and pancreatic models.
Nathan T. La Porte, Jose F. Martinez, Svante Hedström, Benjamin Rudshteyn, Brian T. Phelan, Catherine M. Mauck, Ryan M. Young, Victor S. Batista and Michael R. Wasielewski
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC05103K, Edge Article
Photoinduced electron transfer dynamics are described for a set of dyads comprising rylenediimide anion chromophores and a Re(bpy)(CO)3 metal center.
Yiliang Lin, Yang Liu, Jan Genzer and Michael D. Dickey
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00057J, Edge Article
This paper reports the formation of shape-changing and phase-transforming liquid metal particles that have potential applications in drug delivery, catalysis, colloidal jamming, and optics.

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93 citations
The combination of quantum yield and luminescence quenching measurements provides a method to rapidly characterize the occurrence of chain processes in a variety of photoredox reactions.
DOI: 10.1039/C5SC02185E
Published: 07 Jul 2015
61 citations
Direct splitting of pure water into H2 and O2 in a stoichiometric molar ratio of 2 : 1 by conjugated polymers via a 4-electron pathway was established for the first time, as demonstrated here using a g-C3N4 polymer and redox co-catalysts of Pt and Co species.
DOI: 10.1039/C5SC04572J
Published: 27 Jan 2016
59 citations
This review describes the importance and usefulness of pot-economy and one-pot reactions in current synthetic organic chemistry.
DOI: 10.1039/C5SC02913A
Published: 06 Jan 2016

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