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Chemical Science

For findings of exceptional significance from across the chemical sciences
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Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC04384D, Edge Article
Near infrared (NIR) fluorescence imaging (700–900 nm) is a promising technology in preclinical and clinical tumor diagnosis and therapy. The availability of excellent NIR fluorescent contrast agents is still the...
 
Elizaveta Suturina, Daniel Häussinger, Kaspar Zimmermann, Luca Garbuio, Maxim Yulikov, Gunnar Jeschke and Ilya Kuprov
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC03736D, Edge Article
A significant problem with paramagnetic tags attached to proteins and nucleic acids is their conformational mobility. Each tag is statistically distributed within a volume between 5 and 10 Angstroms across;...
 
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05355F, Edge Article
Three different types of template-directed syntheses of linear porphyrin oligomers are presented. In the classical approach the product has the same number of binding sites as the template, whereas in...
 
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC05092A, Edge Article
A chiral version of the Cp*Ru(COD)Cl complex equipped with an atropchiral cyclopentadienyl (Cpx) ligand enables [2+2]-cycloadditions between bicyclic olefins and alkynes with excellent reactivity and enantioselectivity. A streamlined synthesis of the Cpx ligand by a C–H functionalisation approach is shown. The chloride counterion of the neutral CpxRuII complex is essential for enantioselectivity.
 
Na Li, Huijun Yang, Zhengze Yu, Yanli Li, Wei Pan, Hongyu Wang and Bo Tang
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC04293G, Edge Article
Developing effective nonviral siRNA delivery systems for long-term gene silencing remains a great challenge. Here we present a nuclear-targeted siRNA delivery system that can induce long-term gene silencing in cancer...
 
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05036K, Edge Article
Predicting ground- and excited-state properties of open-shell organic molecules by electronic structure theory can be challenging because an accurate treatment has to correctly describe both static and dynamic electron correlation....
 
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05450A, Edge Article
A Ni(ClO4)2-catalyzed enantioselective [2+2] cycloaddition of Nallenamides with cyclic N-sulfonylketimines was developed, which regioselectively occurred at the proximal C=C bonds of N-allenamides. Broad substrate scope of N-allenamides and cyclic N-sulfonylketimines...
 
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC04633A, Edge Article
Efficient strategies for ultrasensitive imaging of gene expression in living cells are essential for chemistry and cell biology. Here, we report a novel and efficient enzyme-free dual signal amplification strategy...
 
Yuki Inahashi, Shanshan Zhou, Maureen J. Bibb, Lijang Song, Mahmoud M. Al-Bassam, mervyn bibb and Gregory L Challis
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC03533G, Edge Article
2-Hydroxyphenylthiazolines are a family of iron-chelating nonribosomal peptide natural products that function as virulence-conferring siderophores in various Gram-negative bacteria. They have also been reported as metabolites of Gram-positive Streptomyces species....
 
Yining Ji, Hongmin Li, Alan Hyde, Qinghao Chen, Kevin Belyk, Katrina Lexa, Jingjun Yin, Edward Sherer, Robert Thomas Williamson, Andrew Patrick Brunskill, Sumei Ren, Louis-Charles Campeau, I Davies and Rebecca Ruck
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05472B, Edge Article
Significant catalyst loading reduction and increased reaction robustness have been achieved for a Pd-catalyzed asymmetric intramolecular C-N coupling through comprehensive mechanistic studies. Detailed kinetic, spectroscopic, and crystallographic analyses revealed that...
 
Tongdao Wang, Long Wang, Constantin G. Daniliuc, Kamil Samigullin, Matthias Wagner, Gerald Kehr and Gerhard Erker
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC04459J, Edge Article
The reversible enamine/HB(C6F5)2 Lewis adduct reacts with CO by selective head to tail coupling whereas it reacts with NO via a vicinal N/B Lewis pair to give a head to head NO/NO coupling product.
 
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC05135A, Edge Article
We found that plasmonic Au particles on titanium(IV) oxide (TiO2) act as a visible-light-driven photocatalyst for overall water splitting free from any additives.
 
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05421H, Perspective
Drug delivery systems (DDSs) have been extensively studied as carriers to deliver small molecule chemo-drugs to tumors for cancer therapy. The therapeutic efficiency of chemo-drugs is crucially dependent on the...
 
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05065D, Edge Article
We report the direct formation of H2 and O pair ions in single collisions of water ions with metal surfaces at hyperthermal energy. This unusual intra-molecular reaction proceeds also for...
 
Jamie Marie McCabe Dunn, Mikhail Reibarkh, Edward Sherer, Robert Orr, Rebecca Ruck, Bryon Simmons and Ana Bellomo
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05081F, Edge Article
The direct and chemoselective 3’-phosphoramidation, phosphorylation and acylation of nucleosides is described. Upon the discovery of a novel 3’-phosphorylamidation of therapeutic nucleoside analogues with DBU, we explored the mechanism of...
 
Agnes E. Thorarinsdottir, Alexandra I. Gaudette and T. David Harris
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC04287B, Edge Article
The potential utility of paramagnetic transition metal complexes as chemical shift 19F magnetic resonance (MR) thermometers is demonstrated.
 
Paul J. Smith, Simon A. Kondrat, Philip A. Chater, Benjamin R. Yeo, Greg M. Shaw, Li Lu, Jonathan K. Bartley, Stuart H. Taylor, Michael S. Spencer, Christopher J. Kiely, Gordon J. Kelly, Colin W. Park and Graham J. Hutchings
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC04130B, Edge Article
Zincian georgeite, an amorphous copper–zinc hydroxycarbonate, has been prepared by co-precipitation using acetate salts and ammonium carbonate.
 
Oleg G. Salnikov, Hsueh-Ju Liu, Alexey Fedorov, Dudari B. Burueva, Kirill V. Kovtunov, Christophe Copéret and Igor V. Koptyug
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC05276B, Edge Article
Mechanistic insight into the semihydrogenation of 1-butyne and 2-butyne on Cu nanoparticles supported on partially dehydroxylated silica (Cu/SiO2-700) was obtained using parahydrogen.
 
Kalaivanan Nagarajan, Ajith R. Mallia, Keerthi Muraleedharan and Mahesh Hariharan
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC05126J, Edge Article
Core-twisted aromatics exhibit enhanced intersystem crossing upon photoexcitation when compared to their planar analogs.
 
Nagaraju Barsu, Shyam Kumar Bolli and Basker Sundararaju
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC05026C, Edge Article
A general efficient regioselective cobalt catalyzed carbonylation of unactivated C(sp3)–H bonds of aliphatic amides was demonstrated using atmospheric (1–2 atm) carbon monoxide as a C1 source.
 
Kun Zhang, Jie Zhang, Zhen Xi, Luyuan Li, Xiangxiang Gu, Qiangzhe Zhang and Long Yi
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05646F, Edge Article
Near-infrared (NIR) fluorescence-based sensors capable of selective detection of H2S in vivo would be useful tools to understand the mechanisms of diseases. A new NIR fluorescent probe 1 was developed...
 
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC04456E, Edge Article
A DFT study demonstrates that titanium is capable of promoting C–N bond formation via an unconventional reductive elimination pathway featuring back-donation (REBD).
 
Yuping Wang, Junling Sun, Zhichang Liu, Majed S Nassar, Youssry Y. Botros and J. Fraser Stoddart
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05035B, Edge Article
Two potential viologen-based molecular lasso precursors—both composed of a 4,4'-bipyridinium (BIPY2+) unit as part of a rope appended to a cyclobis(paraquat-p-phenylene) (CBPQT4+) loop—that have been designed to mimic the threading...
 
Mihoko Yamada, Nobuto Yoshinari, Naoto Kuwamura, Toru Saito, Satoshi Okada, Sai Prakash MADDALA, Koji Harano, Eiichi Nakamura, Kohei Yamagami, Keisuke YAMANAKA, Akira Sekiyama, Tomoyoshi Suenobu, Yusuke Yamada and Takumi Konno
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC04993A, Edge Article
Unique heterogeneous catalase-like activity was observed for metallosupramolecular ionic crystals [AuI4CoIII2(dppe)2(D-pen)4]Xn ([1]Xn; dppe = 1,2-bis(diphenylphosphino)ethane; D-pen = D-penicillaminate; Xn = (Cl)2, (ClO4)2, (NO3)2 or SO42–) consisting of AuI4CoIII2 complex cations,...
 
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC04541C, Edge Article
The one-step dehydration, decarboxylation and hydrogenation of the bio-based and widely avalaible citric acid is presented. This reaction sequence yields methylsuccinic acid with yields up to 89%. Optimal balances between...
 

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48 citations
Direct splitting of pure water into H2 and O2 in a stoichiometric molar ratio of 2 : 1 by conjugated polymers via a 4-electron pathway was established for the first time, as demonstrated here using a g-C3N4 polymer and redox co-catalysts of Pt and Co species.
DOI: 10.1039/C5SC04572J
Published: 27 Jan 2016
77 citations
The combination of quantum yield and luminescence quenching measurements provides a method to rapidly characterize the occurrence of chain processes in a variety of photoredox reactions.
DOI: 10.1039/C5SC02185E
Published: 07 Jul 2015
20 citations
A mononuclear Dy(iii) complex assembled just from five water molecules and two phosphonic diamide ligands combines the advantages of high anisotropy barrier, high blocking temperature and significant coercivity, apart from its remarkable air- and moisture-stability.
DOI: 10.1039/C6SC00279J
Published: 13 Apr 2016

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