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Journal cover: Chemical Science

Chemical Science

For findings of exceptional significance from across the chemical sciences
All articles free to read, free to publish* from 2015
*Open Access and publication charge waiver extended
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Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00953D, Edge Article
Despite notable recent efforts, a catalytic and convenient strategy for the direct alkylation of unactivated allylic or benzylic sp3 C-H bonds remains a formidable challenge facing the synthesis community. We...
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC01453H, Edge Article
The catalytic activity of artificial enzymes is a sustained challenge. This work designs a porphyrin-based enzymatic network through target-triggered cascade assembly of catalytic nanoparticles. The nanoparticles are synthesized by covalent...
Tim Markovic, Benjamin N. Rocke, David C. Blakemore, Vincent Mascitti and Michael C. Willis
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00675F, Edge Article
Pyridine sulfinates are stable and straightforward to prepare nucleophilic coupling partners for palladium catalyzed cross-coupling reactions with aryl and heteroaryl halides. The scope with respect to the halides coupling partner is considerable, and allows the preparation of a broad range of linked pyridines.
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC01107E, Edge Article
An in-depth computational mechanistic probe of the CuH-mediated hydroamination of internal arylalkynes with amine electrophile and hydrosilane defines the most accessible pathways for rival avenues of direct and reductive hydroamination, from which a general understanding of the factors controlling formal hydroamination catalysis emerges.
Lei Sun, Christopher H. Hendon, Sarah S. Park, Yuri Tulchinsky, Ruomeng Wan, Fang Wang, Aron Walsh and Mircea Dincă
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00647K, Edge Article
Identifying the metal ions that optimize charge transport and charge density in metal–organic frameworks is critical for systematic improvements in the electrical conductivity in these materials.
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00562H, Edge Article
We demonstrate the ability of a molecular Fe2 complex to enable magnetic resonance-based ratiometric quantitation of redox status.
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC01399J, Edge Article
Boron atoms react with acetylene to form an aromatic cyclic-HBC2BH molecule via double C–H bond activation of acetylene in solid neon.
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00831G, Edge Article
The Knoevenagel condensation between α-MIDA boryl acetaldehyde and active methylene compounds enables synthesis of novel electron-poor allylboronates and facilitates access to synthetically challenging thiophene derivatives.
Gokhan Barin, Gregory W. Peterson, Valentina Crocellà, Jun Xu, Kristen A. Colwell, Aditya Nandy, Jeffrey A. Reimer, Silvia Bordiga and Jeffrey R. Long
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC05079D, Edge Article
Efficient removal of ammonia from air is demonstrated in a series of Brønsted acidic porous polymers under dry and humid conditions. The impact of acidic group strength and their spatial distribution on the ammonia uptake is investigated systematically.
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC90023F, Editorial
We would like to take this opportunity to highlight the Outstanding Reviewers for Chemical Science in 2016, as selected by the editorial team for their significant contribution to the journal.
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00137A, Edge Article
We describe a cell-permeable photoswitchable probe capable of modulating epigenetic cellular states by disruption of an essential protein-protein interaction within the MLL1 methyltransferase core complex. Our azobenzene-containing peptides selectively block...
Prashant Shukla, Vinayak S Khodade, Mallojjala SharathChandra, Preeti Chauhan, Saurabh Mishra, Shivakumara Siddaramappa, Eswarappa Pradeep Bulagonda, Amit Singh and Harinath Chakrapani
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00873B, Edge Article
Understanding mechanisms of antimicrobial resistance (AMR) will help launch a counter-offensive against human pathogens that threaten our ability to effectively treat common infections. Here, we report bis(4-nitrobenzyl)sulfanes, which are activated...
Miguel I. Gonzalez, Jarad A. Mason, Eric D. Bloch, Simon J. Teat, Kevin J. Gagnon, Gregory Y. Morrison, Wendy L. Queen and Jeffrey R. Long
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00449D, Edge Article
In situ single-crystal X-ray diffraction experiments enable the direct observation of weak metal–gas interactions in a metal–organic framework.
Marine E. F. Bouduban, Andrés Burgos-Caminal, Rachele Ossola, Joël Teuscher and Jacques-E. Moser
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C6SC05211H, Edge Article
Evidence for an ultrafast light-induced cascade of energy and charge transfer between aggregated quantum-confined nanoplatelets and nanoparticles of CH3NH3PbBr3 perovskite.
Wen Liu, Yingying Mi, Zhe Weng, Yiren Zhong, Zishan Wu and Hailiang Wang
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00668C, Edge Article
Stable-cycling Li metal anode is realized with a MOF layer regulating Li-ion transport and Li deposition via chemical interactions.
Lili Wang, Yaping Feng, Yi Zhou, Meijuan Jia, Guojie Wang, Wei Guo and Lei Jiang
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00153C, Edge Article
2D nanofluidic systems are endowed with photo-responsive ionic rectification by asymmetric modification with spiropyran. Structural and photo-induced charge heterostructures result in smart 2D ionic rectifiers with a maximum rectification ratio of 48.
George M. Burslem, Hannah F. Kyle, Adam Nelson, Thomas A. Edwards and Andrew J. Wilson
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00388A, Perspective
The state of the art in identifying protein–protein interaction inhibitors of hypoxia inducible factor – a promising target for anticancer drug design – is described.
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00215G, Edge Article
The aggregation of Aβ42, linked to Alzheimer's disease, can be altered significantly by variations of the ionic strength of the solution, providing a means to relate the differences in aggregation mechanism of other Ab variants to changes in electrostatic interactions.
Bradley P. Loren, Michael Wleklinski, Andy Koswara, Kathryn Yammine, Yanyang Hu, Zoltan K. Nagy, David H. Thompson and R. Graham Cooks
Chem. Sci., 2017, Advance Article
DOI: 10.1039/C7SC00905D, Edge Article
An integrated system utilizing mass spectrometry for reaction screening, continuous-flow optimization, and continuous crystallization of diphenhydramine has been developed.
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC01159H, Edge Article
Cellular processes occur through the orchestration of multi-step molecular reactions. Reaction progress kinetic analysis (RPKA) can provide mechanistic details to elucidate the multi-step molecular reactions. However, current tools have limited...
Nicolas Brun, Peter Hesemann and Davide Esposito
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00936D, Perspective
Biorefinery aims at the conversion of biomass and renewable feedstocks into fuels and platform chemicals, in analogy to conventional oil refinery. In the past years, the scientific community has defined...
Amanda Morgenstern, Matthew Jaszai, Mark E Eberhart and Anastassia Alexandrova
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC01301A, Edge Article
Electrostatic preorganization is thought to be a principle factor responsible for the impressive cat- alytic capabilities of enzymes. The full protein structure is believed to facilitate catalysis by exerting a...
Claudia Climent, Mario Barbatti, Michael Wolf, Christopher J. Bardeen and David Casanova
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC01285C, Edge Article
In this study we investigate in detail the photophysics of naphthalene dimers covalently linked by a sulfur atom. We explore and rationalize how the oxidation state of the sulfur-bridging atom...
Tasuku Hirayama, Hitomi Tsuboi, Masato Niwa, Ayaji Miki, Satoki Kadota, Yukie Ikeshita, Kensuke Okuda and Hideko Nagasawa
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C6SC05457A, Edge Article
Iron (Fe) species play a number of biologically and pathologically important roles. Especially, iron is a key element in oxygen sensing in living tissue where its metabolism is intimately linked...
Wanping Chen, Runfa Chen, Qingpei Liu, Yi He, Kun He, Xiaoli Ding, Lijing Kang, Xiaoxiao Guo, Nana Xie, Youxiang Zhou, Yuanyuan Lu, Russell Cox, Istvan Molnar, Mu Li, Yanchun Shao and Fusheng Chen
Chem. Sci., 2017, Accepted Manuscript
DOI: 10.1039/C7SC00475C, Edge Article
Monascus azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual...

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Articles from this journal that are regularly and recently being cited by others. We are trialling this feature to see if it makes it quicker and easier for you to find articles for your research. Read more about how we have created this filtering system.

73 citations
Direct splitting of pure water into H2 and O2 in a stoichiometric molar ratio of 2 : 1 by conjugated polymers via a 4-electron pathway was established for the first time, as demonstrated here using a g-C3N4 polymer and redox co-catalysts of Pt and Co species.
DOI: 10.1039/C5SC04572J
Published: 27 Jan 2016
99 citations
The combination of quantum yield and luminescence quenching measurements provides a method to rapidly characterize the occurrence of chain processes in a variety of photoredox reactions.
DOI: 10.1039/C5SC02185E
Published: 07 Jul 2015
66 citations
This review describes the importance and usefulness of pot-economy and one-pot reactions in current synthetic organic chemistry.
DOI: 10.1039/C5SC02913A
Published: 06 Jan 2016

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