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CHAPTER 2

Biomimetic Materials and Surfaces in Detection

Biomimetic surfaces and materials may be utilized in biosensing applications, harnessing material properties that mimic the natural environment of a biomolecule in order to maintain its functionality, artificially create a complex that takes on the form of a biomolecular structure, or modify an environment to promote cellular affinity. Throughout the scientific literature, there are numerous mechanisms by which this concept may be accomplished. Synthetic lipid membranes, meant to mimic a cellular membrane, have been deposited onto sensor platforms for analyte detection with immobilized functional biomolecules. Natural biomolecules may also be immobilized on transducers, with care taken to protect their functionality (e.g., through polymer linkages), allowing them to operate as sensing units. Synthetic molecular constructs have been developed to mimic the activity of biomolecules. Molecularly imprinted polymers have been created, operating as artificial bioaffinity recognition sites for target molecules. Furthermore, whole cells may be immobilized onto sensing surfaces, acting as sensing units or mimics of larger tissue systems. In this chapter, the relevant literature examples are discussed, highlighting the means by which these biomimetic sensing approaches are accomplished.

Print publication date: 28 Aug 2014
Copyright year: 2014
Print ISBN: 978-1-84973-593-3
PDF eISBN: 978-1-84973-707-4
ePub eISBN: 978-1-78262-299-4
Citation:
From the book series:
Detection Science