The incorporation of fluorine containing fragments into organic molecules plays a pivotal role in medicinal chemistry today. Over the past 20 years, this field has undergone a paradigm shift, with the focus now moving to easily handled fluorinating reagents which are capable of introducing these desired structural motifs into sensitive drug-like scaffolds in a regioselective manner. This chapter will provide an overview of synthetic methods for the introduction of F, CF2H and CF3 groups into organic molecules with a focus on those of prime utility to practicing medicinal chemists.