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N-Heterocyclic carbenes; partakers not just spectators

Since their isolation in 1991, N-heterocyclic carbenes (NHCs) have become ubiquitous in organometallic chemistry and catalysis. In recent years, metal–NHC complexes are also showing significant promise in biomedicine, with the development of highly efficient metal-based drugs for potential application in cancer therapeutics or infectious disease. Many studies have shown that NHC ligands do not always remain innocent, and can themselves undergo unanticipated reactions at the metal centre. This review provides an account of the fascinating reactivity of NHCs at transition metal centres.

Print publication date: 28 Sep 2015
Copyright year: 2016
Print ISBN: 978-1-84973-984-9
PDF eISBN: 978-1-78262-396-0
ePub eISBN: 978-1-78262-715-9