Issue 1, 2011
From the journal:

Chemical Communications

Quantitative, label-free and site-specific monitoring of molecular recognition: a multivariate resonance Raman approach†‡

Stephan Niebling,a   Hannes Y. Kuchelmeister,b   Carsten Schmuckb  and  Sebastian Schlücker*a  

* Corresponding authors

a University of Osnabrück, Department of Physics, Barbarastr. 7, 49069 Osnabrück, Germany
E-mail: sebastian.schluecker@uos.de
Fax: +49 541-96913592
Tel: +49 541-9693592

b Institute of Organic Chemistry, University Duisburg-Essen, Universitätsstr. 7, 45117 Essen, Germany
E-mail: carsten.schmuck@uni-due.de
Fax: +49 201-1834259
Tel: +49 201-1833097

Abstract

A site-specific and quantitative approach for label-free monitoring of molecular recognition is presented. Specifically, the binding site of an artificial receptor is probed selectively by UVRR spectroscopy. The ligand binding constant can be determined by non-negative matrix factorization.

Graphical abstract: Quantitative, label-free and site-specific monitoring of molecular recognition: a multivariate resonance Raman approach

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Article information

DOI
https://doi.org/10.1039/C0CC02052D
Article type
Communication
Submitted
23 Jun 2010
Accepted
17 Aug 2010
First published
07 Sep 2010

Chem. Commun., 2011,47, 568-570

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Quantitative, label-free and site-specific monitoring of molecular recognition: a multivariate resonance Raman approach

S. Niebling, H. Y. Kuchelmeister, C. Schmuck and S. Schlücker, Chem. Commun., 2011, 47, 568 DOI: 10.1039/C0CC02052D

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