Issue 9, 2010
From the journal:

Polymer Chemistry

Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties

Mathurin Grogna,a   Rudi Cloots,b   André Luxen,c   Christine Jérôme,a   Catherine Passirani,d   Nolwenn Lautram,d   Jean-F. Desreuxe  and  Christophe Detrembleur*a  

* Corresponding authors

a Center for Education and Research on Macromolecules (CERM), University of Liège, B6 Sart-Tilman, Liège, Belgium
E-mail: christophe.detrembleur@ulg.ac.be
Fax: +32 4-3663497
Tel: +32 4-3663465

b Laboratoire de chimie inorganique structurale, University of Liège, B6 Sart Tilman, Liège, Belgium

c Cyclotron Research Centre, University of Liège, B6 Sart Tilman, Liège, Belgium

d INSERM, U 646, 10 Rue A Boquel, Angers, France

e Coordination and Radiochemistry, University of Liège, B6 Sart Tilman, Liège, Belgium

Abstract

New micellar macrocontrast agents with improved contrast at high frequencies were designed by grafting a gadolinium based contrast agent onto functional stealth micelles formed by poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) in water. As evidenced by relaxometry measurements and the hemolytic CH50 test, the new contrast agents are of interest as MRI blood pool agents.

Graphical abstract: Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties

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Article information

DOI
https://doi.org/10.1039/C0PY00117A
Article type
Paper
Submitted
16 Apr 2010
Accepted
09 Jul 2010
First published
06 Aug 2010

Polym. Chem., 2010,1, 1485-1490

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Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties

M. Grogna, R. Cloots, A. Luxen, C. Jérôme, C. Passirani, N. Lautram, Jean-F. Desreux and C. Detrembleur, Polym. Chem., 2010, 1, 1485 DOI: 10.1039/C0PY00117A

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