Issue 36, 2017

Mesoporous silica nanoparticles with lactose-mediated targeting effect to deliver platinum(iv) prodrug for liver cancer therapy

Abstract

Chemotherapy is the most common therapeutic strategy for the treatment of unresectable hepatocellular carcinoma. However, the therapeutic efficacy is limited by the low delivery efficiency of chemotherapeutics and severe toxicity towards healthy tissues. To address these challenges, active-targeting mesoporous silica nanoparticles conjugating a platinum(IV) prodrug were developed as a therapy for liver cancer for the first time. Taking advantage of liver-targeting lactobionic acid (LA), the smart nano-carriers not only enhanced the circulation time, but also effectively concentrated at the liver tumor site. Moreover, the conjugated platinum(IV) could be reduced in the reductive tumor environment for the fast release of active platinum(II). The novel targeting and self-responsive drug-loading system offers new prospects for liver cancer chemotherapy.

Graphical abstract: Mesoporous silica nanoparticles with lactose-mediated targeting effect to deliver platinum(iv) prodrug for liver cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
21 Jun 2017
Accepted
21 Aug 2017
First published
21 Aug 2017

J. Mater. Chem. B, 2017,5, 7591-7597

Mesoporous silica nanoparticles with lactose-mediated targeting effect to deliver platinum(IV) prodrug for liver cancer therapy

Z. Wang, P. Wu, Z. He, H. He, W. Rong, J. Li, D. Zhou and Y. Huang, J. Mater. Chem. B, 2017, 5, 7591 DOI: 10.1039/C7TB01704A

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